The purpose of this revised application for a 5-year mentored research scientist development award (KO1) on HIV adherence is to conduct research and training activities to advance the candidate's development as an independent behavioral scientist. The proposed research plan includes a series of studies that build upon each other in the area of HIV medication adherence. Study One is a cross sectional study of the relationship of normal and abnormal personality and treatment adherence in 156 HIV+ clinic patients, with consideration of key covariates such as psychopathology, substance use and substance disorders, readiness for adherence, and social support. Study Two includes two components: a prospective study of risk-related and health-promoting behaviors and their relationship to HIV treatment adherence, and a method development study to refine and validate a time-line follow-back method of assessing medication adherence using a novel telephone reporting system to record patient-reported adherence in 128 subjects. Study Three will investigate the necessary and sufficient components of combination adherence interventions. This study is a 3 level, randomized, 12 week prospective control group investigation of psychosocial adherence interventions to be conducted in 189 HIV+ clinic patients who are initiating highly active antiretroviral therapy (HAART) or changing a HAART regimen. This study will build upon results from studies One and Two in methods and key variables to be considered. Interventions will include treatment as usual in group 1, prospective self monitoring of adherence in Group 2, and a """"""""trial run"""""""" of the selected regimen using vitamins added to prospective self monitoring in Group 3. Results from these studies will provide significant needed information to improve adherence among HIV+ patients taking HAART, and will provide the structure and experiences for the candidate to develop an independent research program on treatment adherence.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01MH001688-02
Application #
6185603
Study Section
Special Emphasis Panel (ZRG1-AARR-8 (01))
Program Officer
Gordon, Christopher M
Project Start
1999-09-10
Project End
2004-08-31
Budget Start
2000-09-01
Budget End
2001-08-31
Support Year
2
Fiscal Year
2000
Total Cost
$118,126
Indirect Cost
Name
Virginia Commonwealth University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
City
Richmond
State
VA
Country
United States
Zip Code
23298
Ingersoll, Karen S; Ceperich, Sherry D; Hettema, Jennifer E et al. (2013) Preconceptional motivational interviewing interventions to reduce alcohol-exposed pregnancy risk. J Subst Abuse Treat 44:407-16
Hettema, Jennifer E; Hosseinbor, Sharzad; Ingersoll, Karen S (2012) Feasibility and reliability of interactive voice response assessment of HIV medication adherence: research and clinical implications. HIV Clin Trials 13:271-7
Ceperich, Sherry Dyche; Ingersoll, Karen S (2011) Motivational interviewing + feedback intervention to reduce alcohol-exposed pregnancy risk among college binge drinkers: determinants and patterns of response. J Behav Med 34:381-95
Ingersoll, Karen S; Cropsey, Karen L; Heckman, Carolyn J (2009) A test of motivational plus nicotine replacement interventions for HIV positive smokers. AIDS Behav 13:545-54
Ingersoll, Karen S; Cohen, Jessye (2008) The impact of medication regimen factors on adherence to chronic treatment: a review of literature. J Behav Med 31:213-24
Floyd, R Louise; Sobell, Mark; Velasquez, Mary M et al. (2007) Preventing alcohol-exposed pregnancies: a randomized controlled trial. Am J Prev Med 32:1-10
Ingersoll, K S; Van Zyl, C; Cropsey, K L (2006) Publishing HIV/AIDS behavioural science reports: An author's guide. AIDS Care 18:674-80
Ingersoll, Karen S; Heckman, Carolyn J (2005) Patient-clinician relationships and treatment system effects on HIV medication adherence. AIDS Behav 9:89-101
Ingersoll, K (2004) The impact of psychiatric symptoms, drug use, and medication regimen on non-adherence to HIV treatment. AIDS Care 16:199-211