Sensory symptoms are among the most commonly reported associated features of autism spectrum disorders (ASD). Sensory abilities develop more rapidly than social and communication skills, and thus if their dysfunction is better understood in ASD, could serve an important role in early identification and intervention. Altered tactile sensitivity is one of the most typical variants of sensory features, but is paradoxically understudied relative to hearing and vision in ASD. The sense of touch in early infancy lays the foundation for the development of communication and social reward throughout development. Thus, a better understanding of tactile dysfunction in ASD is critical. Most experimental work has investigated discriminative touch on the palmar surface of the hand, usually the fingertip. Affiliative or affective touch is believed to be mediated by a unique class of somatosensory afferent (CT fiber) that is absent in the palm. The proposed project undertakes the examination of affective tactile perception in ASD using converging behavioral, neurophysiological, and neuroanatomical techniques. Observational measures of tactile defensiveness will be correlated with diffusion tensor imaging (DTI) data characterizing the strength of thalamocortical circuits, as well as responses from functional magnetic resonance imaging (fMRI) and event-related potentials (ERP) that will elucidate the spatial and temporal characteristics, respectively, of neural response to affective tactile stimuli in ASD. This study of the neurobehavioral basis of affective touch in ASD will add to the existing experimental literature that is primarily focused on discriminative touch, and will complement the existing behavioral literature by exploring neural mechanisms. A better understanding of tactile sensitivity in ASD has significant potential for developing biomarkers for early identification and as a foundation for efficacy studies of sensory-based treatments of ASD.

Public Health Relevance

This project addresses tactile defensiveness in autism spectrum disorders (ASD), which is not only a source of stress for affected individuals and their families, but may provide important clues to the core features of ASD. The project uses converging approaches to answer the question of what aspects of neural structure and function are associated with tactile defensiveness and response to social touch in ASD. The project is expected to provide a better understanding of the under-studied area of tactile perception in ASD, which will eventually lead to new approaches for treatment and early identification.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01MH090232-04
Application #
8597457
Study Section
Child Psychopathology and Developmental Disabilities Study Section (CPDD)
Program Officer
Gilotty, Lisa
Project Start
2011-03-01
Project End
2014-12-31
Budget Start
2014-01-01
Budget End
2014-12-31
Support Year
4
Fiscal Year
2014
Total Cost
$162,562
Indirect Cost
$12,034
Name
Vanderbilt University Medical Center
Department
Psychiatry
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Cascio, Carissa J; Foss-Feig, Jennifer H; Heacock, Jessica et al. (2014) Affective neural response to restricted interests in autism spectrum disorders. J Child Psychol Psychiatry 55:162-71
Pryweller, Jennifer R; Schauder, Kimberly B; Anderson, Adam W et al. (2014) White matter correlates of sensory processing in autism spectrum disorders. Neuroimage Clin 6:379-87
Cascio, Carissa J; Lorenzi, Jill; Baranek, Grace T (2013) Self-reported Pleasantness Ratings and Examiner-Coded Defensiveness in Response to Touch in Children with ASD: Effects of Stimulus Material and Bodily Location. J Autism Dev Disord :
Foss-Feig, Jennifer H; Tadin, Duje; Schauder, Kimberly B et al. (2013) A substantial and unexpected enhancement of motion perception in autism. J Neurosci 33:8243-9
Foss-Feig, Jennifer H; Heacock, Jessica L; Cascio, Carissa J (2012) TACTILE RESPONSIVENESS PATTERNS AND THEIR ASSOCIATION WITH CORE FEATURES IN AUTISM SPECTRUM DISORDERS. Res Autism Spectr Disord 6:337-344