Current estimates place the prevalence of attention-deficit/hyperactivity disorder (ADHD) in the US at 3-5%. The usual age of first diagnosis is between 6-7 years of age when students are first entering school;however, many parents will argue that they observed signs/symptoms of ADHD much earlier. Intriguingly, of all 3-4 year old children diagnosed with ADHD (using traditional parent/teacher interview methods), only about 50% continue to meet diagnostic criteria at age 7. Previous attempts at achieving better diagnostic stability before the age of seven have expanded the number and kinds of behavior that are measured. Although these attempts have slightly improved predictability, no new gold standard for this age range has been achieved. The primary goal of this K01 research plan is to examine the development of the neural systems that mark the transition from signs and symptoms of ADHD to stable ADHD diagnosis. By using neuroimaging to better infer the underlying biology, better prediction of which children who exhibit elevated inattention and hyperactivity at age 3 will continue to exhibit these behaviors at age 7 and beyond may be achieved. Children who continue to meet diagnostic criteria for ADHD after the age of 7 are very likely to continue to meet diagnostic criteria across childhood, and in 40-70% of cases into adulthood. Even if they do not meet criteria for the disorder in adulthood they will, based on their childhood diagnosis, have increased risk for academic failure, social problems, substance use disorder, car accidents, and incarceration. Neuroimaging studies have associated deficits of cognitive control with differential activation of the prefrontal cortex in children and adolescents with and without ADHD ages 8 through adulthood. Less is known, however, about the neural basis of the development of cognitive control in younger children ages 3-7 and how this contributes to the development of ADHD. This is a major gap in knowledge, considering how crucial this time period may be to the continued expression of ADHD symptomology. Researchers have found it challenging to investigate the neuro-developmental roots of executive function because of limitations in our ability to image the brain in children this young. However, techniques allowing EEG data collection in 3-4 year olds and fMRI data collection in 5-7 year olds have recently been perfected and are proposed here.
The usual age of first diagnosis for attention-deficit/hyperactivity disorder (ADHD) is between 6-7 years of age when students are first entering school. However, parents and children can experience the negative effects of high ADHD symptomology long before they enter school, increasing the child's risk of social isolation, learning problems, and parental abuse. However current diagnostic techniques for children younger than 7 are inadequate;of all preschool children diagnosed with ADHD (using traditional methods), only about 50% continue to meet diagnostic criteria at age 7. At the moment, some physicians prescribe stimulant medications to children younger than 7 regardless of the diagnostic complications, other physicians do not. The current study would have the potential to reduce conflict around this issue by providing better diagnostic methods earlier.
|Gold, Andrea L; Sheridan, Margaret A; Peverill, Matthew et al. (2016) Childhood abuse and reduced cortical thickness in brain regions involved in emotional processing. J Child Psychol Psychiatry 57:1154-64|
|McLaughlin, Katie A; Sheridan, Margaret A; Gold, Andrea L et al. (2016) Maltreatment Exposure, Brain Structure, and Fear Conditioning in Children and Adolescents. Neuropsychopharmacology 41:1956-64|
|Busso, Daniel S; McLaughlin, Katie A; Sheridan, Margaret A (2016) Dimensions of Adversity, Physiological Reactivity, and Externalizing Psychopathology in Adolescence: Deprivation and Threat. Psychosom Med :|
|Dennison, Meg J; Sheridan, Margaret A; Busso, Daniel S et al. (2016) Neurobehavioral markers of resilience to depression amongst adolescents exposed to child abuse. J Abnorm Psychol 125:1201-1212|
|Peverill, Matthew; McLaughlin, Katie A; Finn, Amy S et al. (2016) Working memory filtering continues to develop into late adolescence. Dev Cogn Neurosci 18:78-88|
|Rotenstein, Lisa S; Sheridan, Margaret; Garg, Rajesh et al. (2015) Effect of mineralocorticoid receptor blockade on hippocampal-dependent memory in adults with obesity. Obesity (Silver Spring) 23:1136-42|
|Humphreys, Kathryn L; McGoron, Lucy; Sheridan, Margaret A et al. (2015) High-Quality Foster Care Mitigates Callous-Unemotional Traits Following Early Deprivation in Boys: A Randomized Controlled Trial. J Am Acad Child Adolesc Psychiatry 54:977-83|
|McLaughlin, Katie A; Peverill, Matthew; Gold, Andrea L et al. (2015) Child Maltreatment and Neural Systems Underlying Emotion Regulation. J Am Acad Child Adolesc Psychiatry 54:753-62|
|McLaughlin, Katie A; Rith-Najarian, Leslie; Dirks, Melanie A et al. (2015) Low vagal tone magnifies the association between psychosocial stress exposure and internalizing psychopathology in adolescents. J Clin Child Adolesc Psychol 44:314-28|
|McLaughlin, Katie A; Sheridan, Margaret A; Tibu, Florin et al. (2015) Causal effects of the early caregiving environment on development of stress response systems in children. Proc Natl Acad Sci U S A 112:5637-42|
Showing the most recent 10 out of 30 publications