This proposal is for a K01 Mentored Research Scientist Development Award for Dr. Chad Rethorst, Assistant Professor in the Department of Psychiatry at University of Texas Southwestern Medical Center. The K01 award will provide the Dr. Rethorst with the additional training and experience necessary to become an independent investigator studying the effects of physical activity on mental health. The proposed career development plan includes focused coursework, mentorship from a multi-disciplinary group of established researchers and practical research experience. The training plan focuses on two training objectives: (1) training in the design and conduct of RCTs in clinical population, (2) training in psychopathology diagnosis and assessment and (3) advanced training in biostatistical methods. Dr. Madhukar Trivedi will serve as the primary mentor and will oversee the training plan. Dr. Trivedi has extensive experience in the design and conduct of multisite trials in mood disorders. Dr. Steve Blair and Dr. Thomas Carmody will provide additional mentorship. Dr. Blair has extensive experience in conducting RCTs using exercise interventions in clinical populations. Dr. Carmody is an expert in study design and longitudinal analysis of projects in the area of mental health. The research project is a pilot study of an exercise intervention to prevent depression in Hepatitis C patients receiving Interferon-alpha (IFN- ?) treatment. IFN- ? is an efficacious treatment for Hepatitis C (HPC);however, IFN- ? treatment results in a significant increase in depressive symptoms. The potential of an exercise intervention to prevent depression during IFN- ? treatment is supported by longitudinal data demonstrating that physical activity reduces future risk of depression. Furthermore, exercise is efficacious as a stand-alone and/or adjunctive treatment for depression. Participants will be recruited from the Clinical Center for Liver Diseases at UT-Southwestern and randomized to 26 weeks of either: aerobic exercise or a health education control group.
The aims of the pilot study are: 1) to examine the feasibility of recruitment and randomization of eligible HCV patients into an RCT, 2) to examine the feasibility of maintaining participant engagement throughout the duration of the trial, 3) to conduct an analysis of the preliminary efficacy of an exercise intervention in preventing depression in Hepatitis C patients receiving IFN-? treatment, and 4) to conduct an analysis of the preliminary effects of an exercise intervention on mediators of IFN- ? induced depression in HPC patients receiving IFN- ? treatment. The successful completion of the proposed research and training plan will provide the knowledge and experience necessary to progress Dr. Rethorst toward his career goal of becoming an independent investigator examining the role of physical activity in the treatment and prevention of mental illness. Specifically, the data obtained from the proposed pilot study will serve as the basis for an R01 application to be submitted during the final year of the K01 award. The R01 will propose an RCT sufficiently powered to examine the efficacy of an exercise intervention in the prevention of IFN- ? -induced depression.
IFN-? treatment results in a significant increase in depressive symptoms, which can negatively impact treatment adherence and outcomes. The prevention of IFN-?-induced depression will eliminate the physical, psychosocial and economic burdens often associated with depression and can potentially improve treatment adherence and outcomes. If exercise proves to be efficacious in preventing depression in HCV patients, the results may be generalizable to other medically ill groups at risk for depression. Furthermore, the model of IFN- ? induced depression provides strong evidence for the role on inflammation in the development of MDD. Completion of the proposed project will provide further insight into the role of inflammation in the etiology of MDD, while also exploring the role of exercise as a treatment option for MDD patients with elevated systemic inflammation. !
|Rethorst, Chad D; Tu, Jian; Carmody, Thomas J et al. (2016) Atypical depressive symptoms as a predictor of treatment response to exercise in Major Depressive Disorder. J Affect Disord 200:156-8|
|Greer, Tracy L; Trombello, Joseph M; Rethorst, Chad D et al. (2016) IMPROVEMENTS IN PSYCHOSOCIAL FUNCTIONING AND HEALTH-RELATED QUALITY OF LIFE FOLLOWING EXERCISE AUGMENTATION IN PATIENTS WITH TREATMENT RESPONSE BUT NONREMITTED MAJOR DEPRESSIVE DISORDER: RESULTS FROM THE TREAD STUDY. Depress Anxiety 33:870-81|
|Dela Cruz, Adriane M; Carmody, Thomas; Greer, Tracy L et al. (2016) Baseline medical comorbidities in adults randomized in the STRIDE trial for psychostimulant use disorders. Am J Addict 25:215-20|
|Stoutenberg, Mark; Rethorst, Chad D; Lawson, Olivia et al. (2016) Exercise training - A beneficial intervention in the treatment of alcohol use disorders? Drug Alcohol Depend 160:2-11|
|Rethorst, C D; Greer, T L; Toups, M S P et al. (2015) IL-1Î² and BDNF are associated with improvement in hypersomnia but not insomnia following exercise in major depressive disorder. Transl Psychiatry 5:e611|
|Kangas, Julie L; Baldwin, Austin S; Rosenfield, David et al. (2015) Examining the moderating effect of depressive symptoms on the relation between exercise and self-efficacy during the initiation of regular exercise. Health Psychol 34:556-65|
|Sanchez, Katherine; Chartier, Karen G; Greer, Tracy L et al. (2015) Comorbidities and race/ethnicity among adults with stimulant use disorders in residential treatment. J Ethn Subst Abuse 14:79-95|
|Rethorst, Chad D; Bernstein, Ira; Trivedi, Madhukar H (2014) Inflammation, obesity, and metabolic syndrome in depression: analysis of the 2009-2010 National Health and Nutrition Examination Survey (NHANES). J Clin Psychiatry 75:e1428-32|
|dela Cruz, Adriane M; Bernstein, Ira H; Greer, Tracy L et al. (2014) Self-rated measure of pain frequency, intensity, and burden: psychometric properties of a new instrument for the assessment of pain. J Psychiatr Res 59:155-60|
|Rethorst, Chad D; Greer, Tracy L; Grannemann, Bruce et al. (2014) A Health Education Intervention as the Control Condition in the CTN-0037 STRIDE multi-site exercise trial: Rationale and Description. Ment Health Phys Act 7:37-41|