The candidate needs additional knowledge skills in developmental neurobiology to allow her to continue her long-term goals of elucidating factors that affect the health and well-being of infants, and to develop age appropriate, non-invasive tests that will identify infants who are at greatest risk for Sudden infant death syndrome (SIDS). For this proposal the candidate will work under the supervision of Dr. Slotkin, Duke University, and Dr. Myers, Columbia University. Both of these researchers are experts in the field of developmental neurobiology and work at research intensive institutions that will offer the experiences for the success of this plan. ? ? Candidate development: ? 1. Complete course work in neurobiology and developmental neurobiology. ? 2. Spend extensive time in the laboratory learning neurobiologic techniques. ? 3. Test the research Aims described below. ? 4. Develop the skills of collaboration, mentoring, leadership, and scientific writing. ? ? Nicotine exposure during pregnancy is responsible for many alterations of neurologic development including; behavioral disorders, depression, addiction, and SIDS. SIDS is the leading cause of infant mortality in developed countries. Infants born to mothers who smoke are 4 times more likely to die of SIDS. Substantial evidence from animal studies shows that nicotine produces impairment of brainstem and autonomic nervous system function consistent with SIDS and other developmental disabilities. The candidate will use an animal model she developed that accounts for environmental, developmental and age risk factors identified for SIDS deaths. Pilot data from this model have already shown an increase in mortality with perinatal nicotine exposure. ? ? Specific research aims: ? Aim 1: Verify the mortality found in pilot data in the nicotine/influenza/endotoxin model ? Aim 2: Establish procedures for assessing autonomic and blood pressure responses ? Aim 3: Determine the autonomic/cardiovascular mechanisms underlying the decreased survival. ? Aim 4: Examine specific actions of autonomic response by blocking sympathetic or parasympathetic pathways with pharmacologic agents. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Nursing Research (NINR)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
1K01NR010910-01
Application #
7513050
Study Section
National Institute of Nursing Research Initial Review Group (NRRC)
Program Officer
Mann Koepke, Kathy M
Project Start
2008-08-01
Project End
2011-07-31
Budget Start
2008-08-01
Budget End
2009-07-31
Support Year
1
Fiscal Year
2008
Total Cost
$86,183
Indirect Cost
Name
Duke University
Department
Type
Schools of Nursing
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Blood-Siegfried, Jane; Rende, Elizabeth K (2010) The long-term effects of prenatal nicotine exposure on neurologic development. J Midwifery Womens Health 55:143-52
Blood-Siegfried, Jane (2009) The role of infection and inflammation in sudden infant death syndrome. Immunopharmacol Immunotoxicol :
Blood-Siegfried, Jane; Bowers, Margaret T; Lorimer, Marcia (2009) Is shock a key element in the pathology of sudden infant death syndrome (SIDS)? Biol Res Nurs 11:187-94
Blood-Siegfried, Jane (2009) The role of infection and inflammation in sudden infant death syndrome. Immunopharmacol Immunotoxicol 31:516-23