Current treatments for alcohol use disorders vary in theoretical foundation and approach, yet are often equally effective across clients who differ substantially in clinical features. Limited progress in client treatment matching, based on our current understanding of mechanisms of behavior change (MOBC), argues strongly for basic to clinical science translation research to provide innovation (Willenbring, 2005). Better understanding of mechanisms that support behavioral flexibility is essential for progress in developing more effective treatments. It would facilitate client-treatment matching by helping to classify clients with different underlying capacities for behavior change, clarify fundamental change processes ctivated by current treatments, and suggest potentially new treatment targets. This K02 competitive renewal application seeks to build upon the knowledge, research skills, and quantitative training the applicant gained during the previous award period to further understand neurobiological and neurocognitive processes that subserve emotional regulation and can act to support or hinder adaptive behavioral change. The overarching goal is to gain expertise in methods that promote translation between basic and clinical science to characterize novel MOBC. Structured, multidisciplinary collaborative expertise and new quantitative skills will be applied to data from the applicant's ongoing research program. NIAAA supported experiments focus on alcohol and placebo challenge effects on implicit memory for, and autonomic nervous system reactivity to, neutral, emotionally valenced and alcohol-related cues in young adult drinkers who are not alcohol dependent. The NIDA supported study focuses on memory and reactivity to the same stimuli, and to drug-related cues, in clinical and high risk samples, and examines the relation of implicit memory and autonomic regulatory processes to intervention outcomes. Skills will also be applied to data from pilot fMRI and genetic studies that recruit participants from these NIH projects to characterize cognitive control processes that operate in bidirectional feedback loops with autonomic reactivity during cue exposure and memory tasks, and test for genetic markers of intermediary phenotypes related to regulatory processes. Support of this application will allow the PI to cross-fertilize theories and methods needed to conduct productive translation research to improve understanding of MOBC in alcoholism treatment, and maximize her contributions to the field.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02AA000325-10
Application #
8107692
Study Section
Special Emphasis Panel (ZAA1-EE (93))
Program Officer
Matochik, John A
Project Start
2001-08-01
Project End
2013-06-30
Budget Start
2011-07-01
Budget End
2013-06-30
Support Year
10
Fiscal Year
2011
Total Cost
$157,670
Indirect Cost
Name
Rutgers University
Department
Psychology
Type
Other Domestic Higher Education
DUNS #
001912864
City
New Brunswick
State
NJ
Country
United States
Zip Code
08901
Nguyen-Louie, Tam T; Buckman, Jennifer F; Ray, Suchismita et al. (2016) Drinkers' memory bias for alcohol picture cues in explicit and implicit memory tasks. Drug Alcohol Depend 160:90-6
Alderman, Brandon L; Olson, Ryan L; Bates, Marsha E et al. (2015) Rumination in major depressive disorder is associated with impaired neural activation during conflict monitoring. Front Hum Neurosci 9:269
Vaschillo, Evgeny G; Vaschillo, Bronya; Buckman, Jennifer F et al. (2015) The effects of sighing on the cardiovascular system. Biol Psychol 106:86-95
Buckman, Jennifer F; Eddie, David; Vaschillo, Evgeny G et al. (2015) Immediate and Complex Cardiovascular Adaptation to an Acute Alcohol Dose. Alcohol Clin Exp Res 39:2334-44
Eddie, D; Kim, C; Lehrer, P et al. (2014) A pilot study of brief heart rate variability biofeedback to reduce craving in young adult men receiving inpatient treatment for substance use disorders. Appl Psychophysiol Biofeedback 39:181-92
Fonoberova, Maria; Mezi?, Igor; Buckman, Jennifer F et al. (2014) A computational physiology approach to personalized treatment models: the beneficial effects of slow breathing on the human cardiovascular system. Am J Physiol Heart Circ Physiol 307:H1073-91
Ray, Suchismita; Pandina, Robert; Bates, Marsha E (2014) Memory for drug-related visual stimuli in young adult, cocaine-dependent polydrug users. Am J Drug Alcohol Abuse 40:170-5
Eddie, D; Buckman, J F; Mun, E Y et al. (2013) Different associations of alcohol cue reactivity with negative alcohol expectancies in mandated and inpatient samples of young adults. Addict Behav 38:2040-3
Udo, Tomoko; Mun, Eun-Young; Buckman, Jennifer F et al. (2013) Potential side effects of unhealthy lifestyle choices and health risks on basal and reactive heart rate variability in college drinkers. J Stud Alcohol Drugs 74:787-96
Lehrer, Paul; Buckman, Jennifer F; Mun, Eun-Young et al. (2013) Negative mood and alcohol problems are related to respiratory dynamics in young adults. Appl Psychophysiol Biofeedback 38:273-83

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