The objective of this K02 application is to allow the candidate to increase the time he has allocated to research and related career development activities from a projected annual average of between 25-45% without the K02 to between 75-80% with the K02. The application overviews the candidate's 15-year history of NI/ AA-supported alcohol research and provides a career development plan aimed at acquiring and deploying sophisticated data analytic and methodological strategies that fall under the broad heading of latent variable-structural equation modeling (LV-SEM) (e.g., factor analysis, path analysis, latent class and trait modeling, growth mixture modeling, item response theory). This would be accomplished via specific career development objectives involving: 1) interactions with mentors and collaborators (15%);2) hypotheses testing (25%);3) formal courses/training (25%);4) scholarly production (25%);and, 5) teaching/ service (10%). The "parent R01" ("CBT Treatment of Anxiety Disorders in Comorbid Alcoholics" / A0105069) targets a sample of 400 patients undergoing a standard community-based alcoholism treatment program who are also diagnosed with at least one of several common comorbid anxiety and affective ("internalizing") disorders. In addition to the alcohol treatment, patients receive one of two psychosocial treatments for internalizing disorder. LV-SEM would allow the candidate to empirically partition highly inter- correlated internalizing disorders/symptoms in the parent R01 dataset into distinct vs. common components that could then be related in causal models to the alcohol and internalizing treatment outcomes. Next, the candidate would replicate these models in community, student and psychiatric-based datasets that are either publicly available (e.g., NESARC) or available via his collaborators (e.g., Drs. Ken Sher and Carrie Randall). These efforts would provide an empirically parsimonious characterization of the internalizing problems experienced by individuals with alcohol use disorders and how these relate to alcoholism and psychiatric treatments across a number of populations and treatment modalities. The longer-term goal would be to develop more effective treatments for alcohol disorders with comorbid internalizing disorders.
By further clarifying the best clinical strategies for and conceptualization of internalizing disorders occurring in alcoholism treatment patients, the proposed work will improve our ability to effectively treat alcohol dependence.
|Kushner, Matt G (2014) Seventy-five years of comorbidity research. J Stud Alcohol Drugs Suppl 75 Suppl 17:50-8|
|Verges, Alvaro; Kushner, Matt G; Jackson, Kristina M et al. (2014) Personality disorders and the persistence of anxiety disorders: evidence of a time-of-measurement effect in NESARC. J Anxiety Disord 28:178-86|
|Kushner, M G; Krueger, R F; Wall, M M et al. (2013) Modeling and treating internalizing psychopathology in a clinical trial: a latent variable structural equation modeling approach. Psychol Med 43:1611-23|
|Kushner, Matt G; Maurer, Eric W; Thuras, Paul et al. (2013) Hybrid cognitive behavioral therapy versus relaxation training for co-occurring anxiety and alcohol disorder: a randomized clinical trial. J Consult Clin Psychol 81:429-42|
|Book, Sarah W; Thomas, Suzanne E; Smith, Joshua P et al. (2013) Treating individuals with social anxiety disorder and at-risk drinking: phasing in a brief alcohol intervention following paroxetine. J Anxiety Disord 27:252-8|
|Kushner, Matt G; Wall, Melanie M; Krueger, Robert F et al. (2012) Alcohol dependence is related to overall internalizing psychopathology load rather than to particular internalizing disorders: evidence from a national sample. Alcohol Clin Exp Res 36:325-31|
|Kushner, Matt G; Maurer, Eric; Menary, Kyle et al. (2011) Vulnerability to the rapid ("telescoped") development of alcohol dependence in individuals with anxiety disorder. J Stud Alcohol Drugs 72:1019-27|