Radiation exposure can occur from medical imaging and therapy, natural background radiation from cosmic rays or radon, and intentional exposure through radiation bioterrorism. This Independent Scientist Award will give me the opportunity to focus on research to dissect mechanisms of radiation response and injury by utilizing genetically engineered mice. Ultimately, this information will lay the groundwork for improved cancer therapy, space exploration, and novel countermeasures against radiation. This Independent Scientist (K02) award will support Dr. Kirsch to use mouse genetics to study mechanisms of acute and late effects from radiation therapy. These in vivo studies will provide a mechanistic foundation for the design of safe and effective countermeasures against radiation that do not inadvertently increase late effects of radiation.

Public Health Relevance

This Independent Scientist (K02) award will support Dr. Kirsch to use mouse genetics to study mechanisms of acute and late effects from radiation therapy. These in vivo studies will provide a mechanistic foundation for the design of safe and effective countermeasures against radiation that do not inadvertently increase late effects of radiation.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Scientist Development Award - Research (K02)
Project #
1K02AI093866-01
Application #
8092233
Study Section
Allergy & Clinical Immunology-1 (AITC)
Program Officer
Prograis, Lawrence J
Project Start
2011-02-03
Project End
2016-01-31
Budget Start
2011-02-03
Budget End
2012-01-31
Support Year
1
Fiscal Year
2011
Total Cost
$100,562
Indirect Cost
Name
Duke University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Moding, Everett J; Mowery, Yvonne M; Kirsch, David G (2016) Opportunities for Radiosensitization in the Stereotactic Body Radiation Therapy (SBRT) Era. Cancer J 22:267-73
Cramer, C K; Yoon, S W; Reinsvold, M et al. (2015) Treatment Planning and Delivery of Whole Brain Irradiation with Hippocampal Avoidance in Rats. PLoS One 10:e0143208
Nussbaum, Daniel P; Speicher, Paul J; Gulack, Brian C et al. (2015) Long-term Oncologic Outcomes After Neoadjuvant Radiation Therapy for Retroperitoneal Sarcomas. Ann Surg 262:163-70
Perez, Bradford A; Mettu, Pradeep; Vajzovic, Lejla et al. (2014) Uveal melanoma treated with iodine-125 episcleral plaque: an analysis of dose on disease control and visual outcomes. Int J Radiat Oncol Biol Phys 89:127-36
Moding, Everett J; Lee, Chang-Lung; Castle, Katherine D et al. (2014) Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium. J Clin Invest 124:3325-38
Phesse, Toby J; Buchert, Michael; Stuart, Emma et al. (2014) Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-?-catenin-mediated intestinal tumor growth and regeneration. Sci Signal 7:ra92
Wong, Philip; Houghton, Peter; Kirsch, David G et al. (2014) Combining targeted agents with modern radiotherapy in soft tissue sarcomas. J Natl Cancer Inst 106:
Nussbaum, Daniel P; Speicher, Paul J; Gulack, Brian C et al. (2014) The effect of neoadjuvant radiation therapy on perioperative outcomes among patients undergoing resection of retroperitoneal sarcomas. Surg Oncol 23:155-60
Khanna, Chand; Fan, Timothy M; Gorlick, Richard et al. (2014) Toward a drug development path that targets metastatic progression in osteosarcoma. Clin Cancer Res 20:4200-9
Lee, Chang-Lung; Lento, William E; Castle, Katherine D et al. (2014) Inhibiting glycogen synthase kinase-3 mitigates the hematopoietic acute radiation syndrome in mice. Radiat Res 181:445-51

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