The overall aim of this revised competing continuation of an Independent Scientist Award is to continue the development of the principal investigator as a clinical scientist. The focus of research for the P.I. is the neurobiology of impulse control as it relates to initiation and maintenance of substance abuse. During the initial 5 years of funding, the principal investigator, F. Gerard Moeller, M.D., developed his expertise in the area of impulsivity, serotonin and substance abuse. The overall goals of this application will be to extend the understanding of impulse control and substance abuse developed through the initially funded Independent Scientist Award with new techniques and collaborations. Once the underlying neurobiology of these behaviors is determined, this will allow development of treatments for impulsivity, which leads to behaviors such as drug abuse or impulsive sexual behaviors that increase the risk for HIV transmission. The primary focus of this application will be to gain additional training in basic and behavioral techniques related to brain imaging in substance dependent subjects. This will be accomplished through two primary short term goals: 1) To obtain additional training in functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) as they relate to impulse control in substance abuse. 2) To develop behavioral techniques for use in brain imaging to measure activation of key brain regions related to impulse control and substance abuse, including the prefrontal cortex and amygdala. In addition to the primary aims of this independent scientist award, there are two secondary aims: 1) to develop tools to examine the role of impulsivity in risky sexual behavior as a risk factor for HIV infection. 2) To develop the investigator as a mentor of junior Psychiatrists who are interested in a career in substance abuse research. The long-term goal of this application is to develop the principal investigator as a senior scientist with the expertise to bridge the gap between basic behavioral science, neurobiology, and treatment in substance abuse. The research plan draws heavily from R01DA15345, and the competing renewal of R01DA08425, on which the author is the principal investigator.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02DA000403-09
Application #
7797644
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Gordon, Harold
Project Start
2000-09-01
Project End
2012-03-31
Budget Start
2010-04-01
Budget End
2011-03-31
Support Year
9
Fiscal Year
2010
Total Cost
$117,612
Indirect Cost
Name
University of Texas Health Science Center Houston
Department
Psychiatry
Type
Schools of Medicine
DUNS #
800771594
City
Houston
State
TX
Country
United States
Zip Code
77225
Lijffijt, Marijn; Lane, Scott D; Moeller, F Gerard et al. (2015) Trait impulsivity and increased pre-attentional sensitivity to intense stimuli in bipolar disorder and controls. J Psychiatr Res 60:73-80
De La Garza 2nd, Richard; Bubar, Marcy J; Carbone, Crystal L et al. (2015) Evaluation of the dopamine ?-hydroxylase (D?H) inhibitor nepicastat in participants who meet criteria for cocaine use disorder. Prog Neuropsychopharmacol Biol Psychiatry 59:40-8
Anastasio, N C; Liu, S; Maili, L et al. (2014) Variation within the serotonin (5-HT) 5-HT?C receptor system aligns with vulnerability to cocaine cue reactivity. Transl Psychiatry 4:e369
Anastasio, Noelle C; Stutz, Sonja J; Fox, Robert G et al. (2014) Functional status of the serotonin 5-HT2C receptor (5-HT2CR) drives interlocked phenotypes that precipitate relapse-like behaviors in cocaine dependence. Neuropsychopharmacology 39:370-82
Ma, Liangsuo; Steinberg, Joel L; Hasan, Khader M et al. (2014) Stochastic dynamic causal modeling of working memory connections in cocaine dependence. Hum Brain Mapp 35:760-78
Cunningham, Kathryn A; Anastasio, Noelle C; Fox, Robert G et al. (2013) Synergism between a serotonin 5-HT2A receptor (5-HT2AR) antagonist and 5-HT2CR agonist suggests new pharmacotherapeutics for cocaine addiction. ACS Chem Neurosci 4:110-21
Swann, Alan C; Lijffijt, Marijn; Lane, Scott D et al. (2013) Antisocial personality disorder and borderline symptoms are differentially related to impulsivity and course of illness in bipolar disorder. J Affect Disord 148:384-90
Liu, Shijing; Lane, Scott D; Schmitz, Joy M et al. (2013) Effects of escitalopram on attentional bias to cocaine-related stimuli and inhibitory control in cocaine-dependent subjects. J Psychopharmacol 27:801-7
Swann, Alan C; Lijffijt, Marijn; Lane, Scott D et al. (2013) Pre-attentive information processing and impulsivity in bipolar disorder. J Psychiatr Res 47:1917-24
Swann, Alan C; Lijffijt, Marijn; Lane, Scott D et al. (2013) Norepinephrine and impulsivity: effects of acute yohimbine. Psychopharmacology (Berl) 229:83-94

Showing the most recent 10 out of 50 publications