This renewal application for an independent scientist award (K02) seeks to support the candidate toward gaining knowledge and acquiring necessary skills for incorporating genetics into his investigations on the developmental pathways of youth drug behaviors, including substance use disorders (SUDs). The intensive period of study afforded by the renewal K02 will involve course work, workshops and consultations with experts in the field of genetics and addictions. Supported by a funded R01, the research development plan will enhance the analysis of current longitudinal data sets and the development of future studies of existing prospective samples. Specific career development goals include: (1) gaining an understanding of the use of state-of-the-art methodologies pertaining to collecting, storing and genotyping genetic material for use in genetic analyses;(2) developing expertise in the use of statistical techniques on longitudinal data involving genetic and environmental variables;(3) gaining expertise in applying gene-environment analyses to existing prospective data sets in order to test and validate gene-environment models that inform our understanding of developmental pathways of adolescent drug use behaviors;and (4) continuing a commitment to teaching service and responsible conduct of science. The applicant's enhanced research skills in genetics will be applied to existing prospective longitudinal samples in order to advance knowledge on the causes and consequences of youth drug use behaviors. These samples represent three groups: high-risk (n=274), treatment (n=393), and matched control (n=190). All samples have already been followed at multiple points (4 waves of assessment) up to their current young adult status (average age is 22.1 years), and the supporting R01 will include two more waves of assessment and the collection of DNA. Study hypotheses will focus on genetic influences, and the interplay of genetic and nongenetic factors on the course and pattern of developmental pathways of youth drug use behaviors.
By further clarifying the nature of developmental pathways of youth drug abuse, prevention and treatment efforts can be better informed.
|Symmes, Amanda; Winters, Ken C; Fahnhorst, Tamara et al. (2015) The Association Between Attention-Deficit Hyperactivity Disorder and Nicotine Use Among Adolescents and Young Adults. J Child Adolesc Subst Abuse 24:37-45|
|Winters, Ken C (2015) Can Parents Provide Brief Intervention Services to Their Drug-Abusing Teenager? J Child Adolesc Subst Abuse 24:134-141|
|Dembo, Richard; Briones-Robinson, Rhissa; Barrett, Kimberly et al. (2014) Brief Intervention for Truant Youth Sexual Risk Behavior and Marijuana Use. J Child Adolesc Subst Abuse 23:318-333|
|Breyer, Jessie L; Lee, Susanne; Winters, Ken C et al. (2014) A longitudinal study of childhood ADHD and substance dependence disorders in early adulthood. Psychol Addict Behav 28:238-46|
|Winters, Ken C; Lee, Susanne; Botzet, Andria et al. (2014) One-year outcomes and mediators of a brief intervention for drug abusing adolescents. Psychol Addict Behav 28:464-74|
|Winters, Ken C (2013) Advances in the science of adolescent drug involvement: implications for assessment and diagnosis - experience from the United States. Curr Opin Psychiatry 26:318-24|
|Dembo, Richard; Briones-Robinson, Rhissa; Barrett, Kimberly et al. (2013) The Mental Health, Substance Use, and Delinquency among Truant Youths in a Brief Intervention Project: A Longitudinal Study. J Emot Behav Disord 21:176-192|
|Kaminer, Yifrah; Winters, Ken C (2012) Proposed DSM-5 substance use disorders for adolescents: if you build it, will they come? Am J Addict 21:280-1; author reply 282|
|Arria, Amelia M; Mericle, Amy A; Meyers, Kathleen et al. (2012) Parental substance use impairment, parenting and substance use disorder risk. J Subst Abuse Treat 43:114-22|
|Winters, Ken C; Fahnhorst, Tamara; Botzet, Andria et al. (2012) Brief intervention for drug-abusing adolescents in a school setting: outcomes and mediating factors. J Subst Abuse Treat 42:279-88|
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