The overall goal of this application for an Independent Scientist Award (K02) is to support the continuing development of the candidate as an independent scientist and facilitate the candidate's interdisciplinary research progrann aimed at a better understanding the determinants and consequences of substance use disorders (SUD). Genetic influences on the liability to addiction are well documented, however, neurobiological mechanisms by which genetic factors contribute to addictive behaviors remain poorly understood. The candidate's major theoretical premise is that genetically transmitted deficits in inhibitory self- regulation of behavior constitute a core component of addiction vulnerability. The candidate's research using quantitative EEG and event-related brain potentials (ERPs) has identified a number of heritable neurophysiological indicators of behavioral regulation, however, limited spatial resolution of electrophy- siology methods impedes the identification of the underlying neural substrates. Accordingly, the candidate's first career objective is to gain expertise in functional magnetic resonance imaging (fMRI) techniques through formal coursework, hands-on training, and developing collaborative projects with neuroimaging researchers at Washington University. The second career objective is to increase the candidate's expertise in advanced methods for the analysis of genetically informative longitudinal data such as latent growth and latent class transition modeling. The research plan draws upon the candidate's ongoing studies of adolescent and young adult twins. Specific research aims are: 1) to identify neurocognitive endophenotypes for addiction and establish their commonality versus specificity and their ability to prospectively predict substance use and abuse;2) to better characterize neural substrates of inhibitory self-regulation of behavior by adding functional neuroimaging assessments to the Pi's ongoing studies and integrating genetic, fMRI, and ERP data;3) to provide a functional validation of genetic variants implicated in addiction vulnerability using a combination EEG, ERPs, functional MRI, neuropsychological testing, and diagnostic assessments. In the long run, establishing the links between genes, brain function, and inhibitory control of behavior will lead to a better understanding of the pathways to addiction and identify targets for prevention and treatment efforts.

Public Health Relevance

Research has documented the role of genetic factors in addictions, but very little is known about how genes exert their influence'on complex behaviors. Investigating the neurobiological pathways and cognitive processes mediating genetic influences on behavior will lead to a better understanding of the pathways to addiction and identify targets for prevention and treatment efforts.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Research Scientist Development Award - Research (K02)
Project #
Application #
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Gordon, Harold
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Washington University
Schools of Medicine
Saint Louis
United States
Zip Code
Golosheykin, Simon; Grant, Julia D; Novak, Olga V et al. (2016) Genetic influences on heart rate variability. Int J Psychophysiol :
Müller, Viktor; Anokhin, Andrey P; Lindenberger, Ulman (2016) Genetic influences on phase synchrony of brain oscillations supporting response inhibition. Int J Psychophysiol :
Anokhin, Andrey P; Golosheykin, Simon (2016) Neural Correlates of Response Inhibition in Adolescents Prospectively Predict Regular Tobacco Smoking. Dev Neuropsychol 41:22-37
Pagliaccio, David; Luking, Katherine R; Anokhin, Andrey P et al. (2016) Revising the BIS/BAS Scale to study development: Measurement invariance and normative effects of age and sex from childhood through adulthood. Psychol Assess 28:429-42
Anokhin, Andrey P; Golosheykin, Simon; Mulligan, Richard C (2015) Long-term test-retest reliability of delayed reward discounting in adolescents. Behav Processes 111:55-9
Anokhin, Andrey P; Grant, Julia D; Mulligan, Richard C et al. (2015) The genetics of impulsivity: evidence for the heritability of delay discounting. Biol Psychiatry 77:887-94
Anokhin, Andrey P; Golosheykin, Simon (2015) Neural correlates of error monitoring in adolescents prospectively predict initiation of tobacco use. Dev Cogn Neurosci 16:166-73
Anokhin, Andrey P (2014) Genetic psychophysiology: advances, problems, and future directions. Int J Psychophysiol 93:173-97
Mulligan, Richard C; Kristjansson, Sean D; Reiersen, Angela M et al. (2014) Neural correlates of inhibitory control and functional genetic variation in the dopamine D4 receptor gene. Neuropsychologia 62:306-18
Anokhin, Andrey P; Golosheykin, Simon; Grant, Julia D et al. (2011) Heritability of delay discounting in adolescence: a longitudinal twin study. Behav Genet 41:175-83

Showing the most recent 10 out of 12 publications