This is an Independent Scientist Career Development Award Application (K02). It is designed to enhance the applicant's ability to integrate cancer bioinformatics with proteomics/ tumor biomarkers. The candidate is an Associate Professor of Dentistry at the University of Michigan. She is an established and productive dentistscientist with R01 funding from the NIH. She has developed an exciting translational research program in identification and validation of biomarkers of detection and progression of head and neck squamous cell carcinoma. The K02 award will further her research career by providing her relief from teaching and service thereby providing her with uninterrupted time to focus on scholarly activities. It would allow her to acquire the expertise to be an informed user of cancer bioinformatics, an essential component of cancer biology research. The candidate plans to use this time to develop didactic and practical bioinformatics knowledge to identify and study biomarkers of relevance to head and neck cancer biology. In order to accomplish this, she will take advantage of available Translational Pathology and strong Cancer Bioinformatics resources and spend time on intensive research in her current research projects. This expertise will accelerate her progress in validation of E-cadherin, rapl and a5?1 integrin as tumor progression biomarkers and facilitate her research in identification and validation of novel signaling proteins that are involved in this molecular network. She will also use this time to become more integrated in the translational pathology community, which will lead to productive collaborations and efficient utilization of resources. Acquisition of a thorough understanding of cancer bioinformatics will allow her to foster collaborations with other head and neck cancer researchers and to accelerate her progress in the identification of head and neck cancer biomarkers. The cancer bioinformatics expertise will also help her other research interest in early detection biomarkers. The immediate goal is to use published microarray studies in a searchable platform with molecular concept modeling, to multiplex the cancer biomarkers being investigated in her laboratory with other biomarkers, such as p53, to determine the extent to which a highly specific and sensitive panel of markers of tumor progression can be developed. The long term goal is to use a meta-analysis approach in the context of the data mining platform to uncover novel signatures of tumor detection, progression and metastasis. Putative biomarkers will be validated in vitro and in vivo. Public Health Relevance: This is an Independent Scientist Career Development Award Application (K02). It will further Dr. D'Silva's research career by providing her relief from teaching and service thereby providing her with uninterrupted time to focus on scholarly activities. It would allow her to acquire the expertise to be an informed user of cancer bioinformatics, an essential component of cancer biology research. The candidate plans to use this time to develop didactic and practical bioinformatics knowledge to identify and study biomarkers of relevance to head and neck cancer biology.

Public Health Relevance

This is an Independent Scientist Career Development Award Application (K02). It will further Dr. D'Silva's research career by providing her relief from teaching and service thereby providing her with uninterrupted time to focus on scholarly activities. It would allow her to acquire the expertise to be an informed user of cancer bioinformatics, an essential component of cancer biology research. The candidate plans to use this time to develop didactic and practical bioinformatics knowledge to identify and study biomarkers of relevance to head and neck cancer biology.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02DE019513-05
Application #
8432362
Study Section
NIDCR Special Grants Review Committee (DSR)
Program Officer
King, Lynn M
Project Start
2009-04-17
Project End
2014-03-31
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
5
Fiscal Year
2013
Total Cost
$94,454
Indirect Cost
$6,997
Name
University of Michigan Ann Arbor
Department
Dentistry
Type
Schools of Dentistry
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Banerjee, Rajat; Russo, Nickole; Liu, Min et al. (2014) TRIP13 promotes error-prone nonhomologous end joining and induces chemoresistance in head and neck cancer. Nat Commun 5:4527
Inglehart, Ronald C; Scanlon, Christina S; D'Silva, Nisha J (2014) Reviewing and reconsidering invasion assays in head and neck cancer. Oral Oncol 50:1137-43
Banerjee, Rajat; Van Tubergen, Elizabeth A; Scanlon, Christina S et al. (2014) The G protein-coupled receptor GALR2 promotes angiogenesis in head and neck cancer. Mol Cancer Ther 13:1323-33
Van Tubergen, Elizabeth A; Banerjee, Rajat; Liu, Min et al. (2013) Inactivation or loss of TTP promotes invasion in head and neck cancer via transcript stabilization and secretion of MMP9, MMP2, and IL-6. Clin Cancer Res 19:1169-79
Scanlon, C S; Van Tubergen, E A; Inglehart, R C et al. (2013) Biomarkers of epithelial-mesenchymal transition in squamous cell carcinoma. J Dent Res 92:114-21
Travan, Suncica; Li, Fei; D'Silva, Nisha J et al. (2013) Differential expression of mitogen activating protein kinases in periodontitis. J Clin Periodontol 40:757-64
Scanlon, Christina S; Van Tubergen, Elizabeth A; Chen, Leng-Chun et al. (2013) Characterization of squamous cell carcinoma in an organotypic culture via subsurface non-linear optical molecular imaging. Exp Biol Med (Maywood) 238:1233-41
Russo, N; Wang, X; Liu, M et al. (2013) A novel approach to biomarker discovery in head and neck cancer using an autoantibody signature. Oncogene 32:5026-37
Zhang, Xiaoyi; Junior, Carlos Rossa; Liu, Min et al. (2013) Oral squamous carcinoma cells secrete RANKL directly supporting osteolytic bone loss. Oral Oncol 49:119-28
Banerjee, Rajat; Henson, Bradley S; Russo, Nickole et al. (2011) Rap1 mediates galanin receptor 2-induced proliferation and survival in squamous cell carcinoma. Cell Signal 23:1110-8

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