Candidate: I am an assistant professor in the Department of Physiology and Cell Biology at the Ohio State University. My department equally values research, teaching, and service. Thus, I currently have a substantial teaching arid service load, which equates to ~60% of my effort. My short-term goals are to expand my research by learning new techniques and to gather new preliminary data to be used to apply for additional multi-year funding (R01, PPG). My long-term goals are to have at least two funded lines of research and to be a recognized leader in the field of nitric oxide signaling in cardiac hnyocytes. Environment: The College of Medicine at OSU greatly supports research. My department has provided me with adequate lab space. Currently, I am PI on a NHLBI R01 and a Co-l on another NHLBl R01. There are ample opportunities for collaboration and multiple core-facilities to which I have full access. Upon award, I will be removed from all service and some teaching commitments to double my research efforts. Research Plan: this plan consists of three sections, the first section is a summary of my R01. the second section is how I would like to expand this project. This (expansion consists of learning new techniques (small animal surgery Nitric oxide is an important regulator of heart function, the production of nitric oxide is altered in many cardiac diseases leading to dysfunction of the heart. The studies proposed here are relevant for public health by potentially improving the treatment of heart diseases.
Public Health Relevance
Nitric oxide is an important regulator of heart function, the production of nitric oxide is altered in many cardiac diseases leading to dysfunction of the heart. The studies proposed here are relevant for public health by potentially improving the treatment of heart diseases.
|Shettigar, Vikram; Zhang, Bo; Little, Sean C et al. (2016) Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease. Nat Commun 7:10794|
|Roof, Steve R; Ho, Hsiang-Ting; Little, Sean C et al. (2015) Obligatory role of neuronal nitric oxide synthase in the heart's antioxidant adaptation with exercise. J Mol Cell Cardiol 81:54-61|
|Zhang, Bo; Davis, Jonathan P; Ziolo, Mark T (2015) Cardiac Catheterization in Mice to Measure the Pressure Volume Relationship: Investigating the Bowditch Effect. J Vis Exp :e52618|
|Tang, Lifei; Wang, Honglan; Ziolo, Mark T (2014) Targeting NOS as a therapeutic approach for heart failure. Pharmacol Ther 142:306-15|
|Ziolo, Mark T; Houser, Steven R (2014) Abnormal Ca(2+) cycling in failing ventricular myocytes: role of NOS1-mediated nitroso-redox balance. Antioxid Redox Signal 21:2044-59|
|Biesiadecki, Brandon J; Davis, Jonathan P; Ziolo, Mark T et al. (2014) Tri-modal regulation of cardiac muscle relaxation; intracellular calcium decline, thin filament deactivation, and cross-bridge cycling kinetics. Biophys Rev 6:273-289|
|Curran, Jerry; Tang, Lifei; Roof, Steve R et al. (2014) Nitric oxide-dependent activation of CaMKII increases diastolic sarcoplasmic reticulum calcium release in cardiac myocytes in response to adrenergic stimulation. PLoS One 9:e87495|
|Sivakumaran, Vidhya; Stanley, Brian A; Tocchetti, Carlo G et al. (2013) HNO enhances SERCA2a activity and cardiomyocyte function by promoting redox-dependent phospholamban oligomerization. Antioxid Redox Signal 19:1185-97|
|Roof, Steve R; Tang, Lifei; Ostler, Joseph E et al. (2013) Neuronal nitric oxide synthase is indispensable for the cardiac adaptive effects of exercise. Basic Res Cardiol 108:332|
|Nixon, Benjamin R; Liu, Bin; Scellini, Beatrice et al. (2013) Tropomyosin Ser-283 pseudo-phosphorylation slows myofibril relaxation. Arch Biochem Biophys 535:30-8|
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