This is an application for a five year Research Scientist Development Grant in which investigations already in progress will be continued and extended and new research will be planned and conducted. The primary focus of the research during the grant period is a longitudinal study of the impact of various childhood physical disabilities on the affected children and their families. The objectives of the study are to assess the consequences of physical disability on 1) the adjustment of the disabled children (in terms of physical, psychological and social functioning), 2) the psychological functioning of normal siblings, and 3) the emotional distress of mothers, and to ascertain the effects of family characteristics and socioeconomic factors on these outcomes. A two wave lontitudinal design will be used in which a sample of families with disabled children will be compared to a randomly selected sample of families. The first wave of data was gathered in 1978 and 1979 in home interviews with 369 mothers of children three to eighteen years old with cystic fibrosis, cerebral palsy, myelodysplasia, and multiple physical handicaps, and 459 mothers from randomly selected households in the same geographic area (Cuyahoga County, Ohio). The second wave of interviews will be conducted in 1983-1984. The availability of a comparison group will enable the separation of the effect of childhood disability from the effects of """"""""normative"""""""" factors influencing the adjustment of family members. Multivariate statistical techniques will be used in cross-sectional comparisons of the two sample and in the study of later outcomes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02MH000380-03
Application #
3069735
Study Section
Research Scientist Development Review Committee (MHK)
Project Start
1982-12-01
Project End
1987-11-30
Budget Start
1984-12-01
Budget End
1985-11-30
Support Year
3
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Breslau, N; Andreski, P (1995) Migraine, personality, and psychiatric comorbidity. Headache 35:382-6
Breslau, N (1995) Psychiatric comorbidity of smoking and nicotine dependence. Behav Genet 25:95-101
Breslau, N; Kilbey, M M; Andreski, P (1994) DSM-III-R nicotine dependence in young adults: prevalence, correlates and associated psychiatric disorders. Addiction 89:743-54
Breslau, N; DelDotto, J E; Brown, G G et al. (1994) A gradient relationship between low birth weight and IQ at age 6 years. Arch Pediatr Adolesc Med 148:377-83
Breslau, N; Davis, G C; Schultz, L R et al. (1994) Joint 1994 Wolff Award Presentation. Migraine and major depression: a longitudinal study. Headache 34:387-93
Davis, G C; Breslau, N (1994) Post-traumatic stress disorder in victims of civilian trauma and criminal violence. Psychiatr Clin North Am 17:289-99
Breslau, N; Kilbey, M M; Andreski, P (1993) Vulnerability to psychopathology in nicotine-dependent smokers: an epidemiologic study of young adults. Am J Psychiatry 150:941-6
Andreski, P; Breslau, N (1993) Smoking and nicotine dependence in young adults: differences between blacks and whites. Drug Alcohol Depend 32:119-25
Breslau, N; Fenn, N; Peterson, E L (1993) Early smoking initiation and nicotine dependence in a cohort of young adults. Drug Alcohol Depend 33:129-37
Breslau, N (1993) Daily cigarette consumption in early adulthood: age of smoking initiation and duration of smoking. Drug Alcohol Depend 33:287-91

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