Abstract

The purpose of the research outlined in the RSDA is to investigate the neurobiology of schizophrenia by integrating clinical, neurobehavioral, neuroanatomic and neurophysiologic measures of brain function. Clinical presentation, premorbid functioning and course will be evaluated in relation to neurobehavioral and neuroimaging measures. The neurobehavioral assessment will evaluate major functions and quantify dimensions of regional brain functioning. Neuroanatomic parameters will be obtained with Magnetic Resonance Imaging (MRI) volumetric measurements, as well as post-mortem neuropathologic studies. Neurophysiologic parameters will consist of regional cerebral blood flow (RCBF) with Xenon-133, and EEG/EP during activation procedures; glucose metabolism and blood flow using Positron Emission Tomography (PET); neuroreception density and affinity will be measured using PET and Single Photon Emission Tomography (SPECT) and postmortem autoradiography receptor functioning. Studies will be performed. A combined MRI/Magnetic Resonance Spectroscopy (MRS) will also be introduced. It is hoped that through this integrative interdisciplinary approach the study of schizophrenia as a brain disease will be advanced.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02MH000586-08
Application #
3069980
Study Section
Research Scientist Development Review Committee (MHK)
Project Start
1985-09-01
Project End
1995-08-31
Budget Start
1992-09-01
Budget End
1993-08-31
Support Year
8
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Dickinson, Dwight; Ragland, J Daniel; Gold, James M et al. (2008) General and specific cognitive deficits in schizophrenia: Goliath defeats David? Biol Psychiatry 64:823-7
Dickinson, Dwight; Ragland, J Daniel; Calkins, Monica E et al. (2006) A comparison of cognitive structure in schizophrenia patients and healthy controls using confirmatory factor analysis. Schizophr Res 85:20-9
Ragland, J Daniel (2003) Profiles of neuropsychologic function in schizophrenia. Curr Psychiatry Rep 5:299-302
Ragland, J Daniel; Turetsky, Bruce I; Gur, Ruben C et al. (2002) Working memory for complex figures: an fMRI comparison of letter and fractal n-back tasks. Neuropsychology 16:370-9
Ragland, J D; Gur, R C; Raz, J et al. (2001) Effect of schizophrenia on frontotemporal activity during word encoding and recognition: a PET cerebral blood flow study. Am J Psychiatry 158:1114-25
Ragland, J D; Gur, R C; Lazarev, M G et al. (2000) Hemispheric activation of anterior and inferior prefrontal cortex during verbal encoding and recognition: a PET study of healthy volunteers. Neuroimage 11:624-33
Ragland, J D; Coleman, A R; Gur, R C et al. (2000) Sex differences in brain-behavior relationships between verbal episodic memory and resting regional cerebral blood flow. Neuropsychologia 38:451-61
Censits, D M; Ragland, J D; Gur, R C et al. (1997) Neuropsychological evidence supporting a neurodevelopmental model of schizophrenia: a longitudinal study. Schizophr Res 24:289-98
Ragland, J D; Glahn, D C; Gur, R C et al. (1997) PET regional cerebral blood flow change during working and declarative memory: relationship with task performance. Neuropsychology 11:222-31
Szymanski, S; Gur, R C; Gallacher, F et al. (1996) Vulnerability to tardive dyskinesia development in schizophrenia: an FDG-PET study of cerebral metabolism. Neuropsychopharmacology 15:567-75

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