Abstract

The goal of this application is to enable Dr. Leuchter's to undertake a new research program focused on cognitive neurophysiology in the elderly. Dr. Leuchter proposes to develop new skills in : 1) the use of cognitive tasks for cerebral activation; 2) the recording of neurophysiologic data during task performance; and 3) the study of cognitive changes in aging. He has selected a panel of expert consultants who will work with him to develop these skills. With the support of this Award, Dr. Leuchter will utilize his quantitative electroencephalography (QEEG) and magnetic resonance imaging (MRI) methods to examine differences in cognition between young and old adults, and to study the cognitive decline that accompanies aging. He will test the following three general hypotheses: 1. Differences in cognition between young and elderly subjects will be reflected in differences in cerebral activation and inhibition accompanying cognitive tasks: 2. Elderly subjects with deep white-matter lesions are at greater risk for cognitive dysfunction than those without these lesions; and 3. Elderly subjects with poor performance on cognitive tasks, who have white-matter lesions that affect the brain systems showing poor performance, will be at greater risk for progressive or global impairment than those without such lesions. Dr. Leuchter has developed enhanced QEEG methods that may provide more information about cerebral activation during tasks than previously possible. He will use these methods in this revised research plan to study 50 young and 100 elderly adults with QEEG during the performance of a battery of cognitive tasks. Some of the elderly subjects will have risk factors for the development of white- matter lesions. Quantitative MRI will be used both the locate recording electrodes in relation to the brain, and to determine the volume of white-matter disease. All subjects will be examined with a neuropsychological test battery, task-activated QEEG, and MRI at entry into the study and at three years. Comparisons will be performed between young and old subjects, and with groups of elderly subjects, to determine if deficient task activation is associated with poorer performance and/or cognitive decline.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02MH001165-04
Application #
2609422
Study Section
Special Emphasis Panel (SRCM (01))
Project Start
1994-12-01
Project End
1999-11-30
Budget Start
1997-12-01
Budget End
1998-11-30
Support Year
4
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Psychiatry
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Caudill, Marissa M; Hunter, Aimee M; Cook, Ian A et al. (2015) The Antidepressant Treatment Response Index as a Predictor of Reboxetine Treatment Outcome in Major Depressive Disorder. Clin EEG Neurosci 46:277-84
Hunter, A M; Leuchter, A F; Cook, I A et al. (2010) Brain functional changes (QEEG cordance) and worsening suicidal ideation and mood symptoms during antidepressant treatment. Acta Psychiatr Scand 122:461-9
Kalechstein, Ari D; De la Garza 2nd, Richard; Newton, Thomas F et al. (2009) Quantitative EEG abnormalities are associated with memory impairment in recently abstinent methamphetamine-dependent individuals. J Neuropsychiatry Clin Neurosci 21:254-8
Leuchter, Andrew F; Cook, Ian A; Hunter, Aimee et al. (2009) Use of clinical neurophysiology for the selection of medication in the treatment of major depressive disorder: the state of the evidence. Clin EEG Neurosci 40:78-83
Leuchter, Andrew F; Cook, Ian A; DeBrota, David J et al. (2008) Changes in brain function during administration of venlafaxine or placebo to normal subjects. Clin EEG Neurosci 39:175-81
Cook, Ian A; Bookheimer, Susan Y; Mickes, Laura et al. (2007) Aging and brain activation with working memory tasks: an fMRI study of connectivity. Int J Geriatr Psychiatry 22:332-42
Morgan, Melinda L; Cook, Ian A; Rapkin, Andrea J et al. (2007) Neurophysiologic changes during estrogen augmentation in perimenopausal depression. Maturitas 56:54-60
Venneman, Sandy; Leuchter, Andrew; Bartzokis, George et al. (2006) Variation in neurophysiological function and evidence of quantitative electroencephalogram discordance: predicting cocaine-dependent treatment attrition. J Neuropsychiatry Clin Neurosci 18:208-16
Hunter, Aimee M; Leuchter, Andrew F; Morgan, Melinda L et al. (2006) Changes in brain function (quantitative EEG cordance) during placebo lead-in and treatment outcomes in clinical trials for major depression. Am J Psychiatry 163:1426-32
Hunter, Aimee M; Leuchter, Andrew F; Morgan, Melinda L et al. (2005) Neurophysiologic correlates of side effects in normal subjects randomized to venlafaxine or placebo. Neuropsychopharmacology 30:792-9

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