In this proposed career development award, I aim to build upon the work of my previous career award. Funded by that award, I examined the relation between prenatal insults and adult schizophrenia spectrum disorders (SSD) in three birth cohorts, and identified several novel associations. In the current award I will extend this work in several ways. First, I will investigate whether early developmental exposures are associated with an increased risk of SSD. Second, I will assess whether early developmental exposures are associated with structural and functional brain abnormalities in patients with SSD. Third, I will examine the relation of genetic vulnerability to early developmental insult in SSD. To achieve this objective I will receive further training in neuroimaging, genetic epidemiology, and other research areas from distinguished experts. This will include direct supervision, formal coursework, readings, and seminars. The research arm of the award will utilize prospectively acquired data on prenatal viral infection and other early developmental insults in two birth cohorts in which I have completed follow-up studies for schizophrenia. Unlike previous studies, serologic analysis will be used to document prenatal viral exposures and cytokine elevations in relation to the risk of schizophrenia. Subjects in these cohorts will receive neuroimaging assessments, including volumetric magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H MRS), and a comprehensive neuropsychological test battery. A summary measure of early developmental insult will then be examined in relation to specific structural and functional brain abnormalities detected by the above methodologies. In the genetics section of the proposal, I will test models of gene-environment interaction. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02MH065422-03
Application #
6902607
Study Section
Social Sciences, Nursing, Epidemiology and Methods 4 (SNEM)
Program Officer
Heinssen, Robert K
Project Start
2003-07-01
Project End
2008-06-30
Budget Start
2005-07-01
Budget End
2006-06-30
Support Year
3
Fiscal Year
2005
Total Cost
$122,666
Indirect Cost
Name
Columbia University (N.Y.)
Department
Psychiatry
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
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Brown, Alan S; Gyllenberg, David; Hinkka-Yli-Salomäki, Susanna et al. (2017) Altered growth trajectory of head circumference during infancy and schizophrenia in a National Birth Cohort. Schizophr Res 182:115-119
Niemelä, Solja; Sourander, Andre; Surcel, Heljä-Marja et al. (2016) Prenatal Nicotine Exposure and Risk of Schizophrenia Among Offspring in a National Birth Cohort. Am J Psychiatry 173:799-806
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Gyllenberg, David; Sourander, Andre; Surcel, Heljä-Marja et al. (2016) Hypothyroxinemia During Gestation and Offspring Schizophrenia in a National Birth Cohort. Biol Psychiatry 79:962-70
Freedman, David; Bao, Yuanyuan; Shen, Ling et al. (2016) Maternal T. gondii, offspring bipolar disorder and neurocognition. Psychiatry Res 243:382-9
Brown, Alan S; Surcel, Heljä-Marja; Hinkka-Yli-Salomäki, Susanna et al. (2015) Maternal thyroid autoantibody and elevated risk of autism in a national birth cohort. Prog Neuropsychopharmacol Biol Psychiatry 57:86-92
Freedman, David; Brown, Alan S; Shen, Ling et al. (2015) Perinatal oxytocin increases the risk of offspring bipolar disorder and childhood cognitive impairment. J Affect Disord 173:65-72

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