Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Modified Research Career Development Award (K04)
Project #
5K04AG000415-05
Application #
3070552
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1988-09-01
Project End
1993-08-31
Budget Start
1992-09-01
Budget End
1993-08-31
Support Year
5
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Kawai, M; Kalaria, R N; Cras, P et al. (1993) Degeneration of vascular muscle cells in cerebral amyloid angiopathy of Alzheimer disease. Brain Res 623:142-6
Perry, G; Cras, P; Siedlak, S L et al. (1992) Beta protein immunoreactivity is found in the majority of neurofibrillary tangles of Alzheimer's disease. Am J Pathol 140:283-90
Perry, G; Richey, P; Siedlak, S L et al. (1992) Basic fibroblast growth factor binds to filamentous inclusions of neurodegenerative diseases. Brain Res 579:350-2
Gollin, P A; Kalaria, R N; Eikelenboom, P et al. (1992) Alpha 1-antitrypsin and alpha 1-antichymotrypsin are in the lesions of Alzheimer's disease. Neuroreport 3:201-3
Medori, R; Tritschler, H J; Gambetti, P (1992) Production of single-stranded DNA for sequencing: an alternative approach. Biotechniques 12:346-50
Kawai, M; Cras, P; Richey, P et al. (1992) Subcellular localization of amyloid precursor protein in senile plaques of Alzheimer's disease. Am J Pathol 140:947-58
Tabaton, M; Cammarata, S; Mancardi, G et al. (1991) Ultrastructural localization of beta-amyloid, tau, and ubiquitin epitopes in extracellular neurofibrillary tangles. Proc Natl Acad Sci U S A 88:2098-102
Siedlak, S L; Cras, P; Kawai, M et al. (1991) Basic fibroblast growth factor binding is a marker for extracellular neurofibrillary tangles in Alzheimer disease. J Histochem Cytochem 39:899-904
Cras, P; Kawai, M; Lowery, D et al. (1991) Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein. Proc Natl Acad Sci U S A 88:7552-6
Kalaria, R N; Galloway, P G; Perry, G (1991) Widespread serum amyloid P immunoreactivity in cortical amyloid deposits and the neurofibrillary pathology of Alzheimer's disease and other degenerative disorders. Neuropathol Appl Neurobiol 17:189-201

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