Dental implants are widely used in clinical practice, yet there are no established criteria regarding the choice of material, design, or surface characteristics which should be employed for these devices. Preliminary information from our laboratory suggests that the surface of commercial implants varies widely and influences the biological response. The goals of this application are to provide the applicant with the skills necessary to approach these problems of biomaterials research by characterizing the effects of materials on the biological responses. The experiments proposed are specifically designed to study a number of variables such as metal selection topography, oxide structure and composition, and surface charge and energy by using surface characterization techniques, including SEM/EDAX, XPS, AES, and contact angle measurements. The effects of these conditions on fundamental biological processes such as matrix deposition and cellular attachment, spreading and proliferation will address the hypothesis that modifications of the implant surface determine biological acceptance ad, thereby long term tissue compatibility. Specific surface characteristics which are important in determining a suitable substratum for biological acceptability will be ascertained. This research has important clinical implications in that it will help define a model implant surface to which there is an optimum tissue response. Mentors and consultants with expertise in the appropriate areas of cell biology and materials surface science have been selected, and a productive research environment chosen, so as to assist the candidate in his long term goal to better understand the effects of material on biological systems.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Modified Research Career Development Award (K04)
Project #
5K04DE000234-02
Application #
3072180
Study Section
Oral Biology and Medicine Subcommittee 1 (OBM)
Project Start
1989-07-01
Project End
1994-06-30
Budget Start
1990-07-01
Budget End
1991-06-30
Support Year
2
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of Iowa
Department
Type
Schools of Dentistry
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Keller, J C (1998) Tissue compatibility to different surfaces of dental implants: in vitro studies. Implant Dent 7:331-7
Vezeau, P J; Koorbusch, G F; Draughn, R A et al. (1996) Effects of multiple sterilization on surface characteristics and in vitro biologic responses to titanium. J Oral Maxillofac Surg 54:738-46
Kuempel, D R; Johnson, G K; Zaharias, R S et al. (1995) The effects of scaling procedures on epithelial cell growth on titanium surfaces. J Periodontol 66:228-34
Niederauer, G G; McGee, T D; Keller, J C et al. (1994) Attachment of epithelial cells and fibroblasts to ceramic materials. Biomaterials 15:342-52
Stanford, C M; Keller, J C; Solursh, M (1994) Bone cell expression on titanium surfaces is altered by sterilization treatments. J Dent Res 73:1061-71
Keller, J C; Stanford, C M; Wightman, J P et al. (1994) Characterizations of titanium implant surfaces. III. J Biomed Mater Res 28:939-46
Swart, K M; Keller, J C; Wightman, J P et al. (1992) Short-term plasma-cleaning treatments enhance in vitro osteoblast attachment to titanium. J Oral Implantol 18:130-7
Michaels, C M; Keller, J C; Stanford, C M (1991) In vitro periodontal ligament fibroblast attachment to plasma-cleaned titanium surfaces. J Oral Implantol 17:132-9