Dr. Ramsay's field of specialization within psychology is behavioral neuroscience. He conducts clinical and behavioral research that is of practical significance to dentistry/medicine and has theoretical importance to our understanding of the brain-behavioral systems underlying drug addiction and drug tolerance. His primary research interest is in the area of drugs and behavior. He has conducted controlled animal experiments as well as human clinical investigations into the role learning plays in modulating drug effects. One of his research interests pertains to individual differences in acute tolerance development and how they might relate to an individual's vulnerability to drug addiction. One of his current experiments investigates the relationship between acute and chronic tolerance development to nitrous oxide anagesia in human volunteers. Dr.Ramsay also studies drug effects on human performance. He is investigating the effects of the benzodiazepine, midazolam, on the control of muscle force with one objective being the better understanding of tolerance development and its possible relationship to precipitated rebound. Dr. Ramsay's research interest include the utility of combining drug therapy with non-pharmacological behavioral and psychotherapeutic approaches to human disorders. He is actively involved in a 5-year project evaluating a possible role of the benzodiazepine, alprazolam, in the cognitive-behavioral treatment of phobic disorders.

National Institute of Health (NIH)
National Institute of Dental & Craniofacial Research (NIDCR)
Modified Research Career Development Award (K04)
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Behavioral Medicine Study Section (BEM)
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University of Washington
Schools of Dentistry
United States
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Inkson, Colette A; Ono, Mitsuaki; Kuznetsov, Sergei A et al. (2008) TGF-beta1 and WISP-1/CCN-4 can regulate each other's activity to cooperatively control osteoblast function. J Cell Biochem 104:1865-78
Coldwell, Susan E; Wilhelm, Frank H; Milgrom, Peter et al. (2007) Combining alprazolam with systematic desensitization therapy for dental injection phobia. J Anxiety Disord 21:871-87
Ramsay, Douglas S; Leroux, Brian G; Rothen, Marilynn et al. (2005) Nitrous oxide analgesia in humans: acute and chronic tolerance. Pain 114:19-28
Ashmore, Jennifer L; Kurland, Brenda F; King, Gregory J et al. (2002) A 3-dimensional analysis of molar movement during headgear treatment. Am J Orthod Dentofacial Orthop 121:18-29; discussion 29-30
Kaakko, T; Murtomaa, H; Milgrom, P et al. (2001) Recruiting phobic research subjects: effectiveness and cost. Anesth Prog 48:3-8
Kaiyala, K J; Leroux, B G; Watson, C H et al. (2001) Reliability of individual differences in initial sensitivity and acute tolerance to nitrous oxide hypothermia. Pharmacol Biochem Behav 68:691-9
Justus, T; Chang, B L; Bloomquist, D et al. (2001) Human gingival and pulpal blood flow during healing after Le Fort I osteotomy. J Oral Maxillofac Surg 59:2-7; discussion 7-8
Kaakko, T; Coldwell, S E; Getz, T et al. (2000) Psychiatric diagnoses among self-referred dental injection phobics. J Anxiety Disord 14:299-312
Woods, S C; Ramsay, D S (2000) Pavlovian influences over food and drug intake. Behav Brain Res 110:175-82
Nakai, Y; Milgrom, P; Mancl, L et al. (2000) Effectiveness of local anesthesia in pediatric dental practice. J Am Dent Assoc 131:1699-705

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