Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Modified Research Career Development Award (K04)
Project #
5K04DK002217-03
Application #
2134034
Study Section
Endocrinology Study Section (END)
Project Start
1994-01-01
Project End
1998-12-31
Budget Start
1996-01-19
Budget End
1996-12-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Pathology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Gao, Zhiyong; Young, Robert A; Li, Guizhu et al. (2003) Distinguishing features of leucine and alpha-ketoisocaproate sensing in pancreatic beta-cells. Endocrinology 144:1949-57
Major, C D; Gao, Z Y; Wolf, B A (1999) Activation of the sphingomyelinase/ceramide signal transduction pathway in insulin-secreting beta-cells: role in cytokine-induced beta-cell death. Diabetes 48:1372-80
Jolly-Tornetta, C; Gao, Z Y; Lee, V M et al. (1998) Regulation of amyloid precursor protein secretion by glutamate receptors in human Ntera 2 neurons. J Biol Chem 273:14015-21
Gao, Z; Konrad, R J; Collins, H et al. (1996) Wortmannin inhibits insulin secretion in pancreatic islets and beta-TC3 cells independent of its inhibition of phosphatidylinositol 3-kinase. Diabetes 45:854-62
Konrad, R J; Dean, R M; Young, R A et al. (1996) Glucose-induced tyrosine phosphorylation of p125 in beta cells and pancreatic islets. A novel proximal signal in insulin secretion. J Biol Chem 271:24179-86
Chen, M; Yang, Z; Naji, A et al. (1996) Identification of calcium-dependent phospholipase A2 isoforms in human and rat pancreatic islets and insulin secreting beta-cell lines. Endocrinology 137:2901-9
Konard, R J; Stoller, J Z; Gao, Z Y et al. (1996) Eicosapentaenoic acid (C20:5) augments glucose-induced insulin secretion from beta-TC3 insulinoma cells. Pancreas 13:253-8
Rothenberg, P L; Willison, L D; Simon, J et al. (1995) Glucose-induced insulin receptor tyrosine phosphorylation in insulin-secreting beta-cells. Diabetes 44:802-9
Alter, C A; Wolf, B A (1995) Identification of phosphatidylinositol 3,4,5-trisphosphate in pancreatic islets and insulin-secreting beta-cells. Biochem Biophys Res Commun 208:190-7
Major, C; Wolf, B A (1994) Quantitation of the fatty acid composition of phosphatidic acid by capillary gas chromatography electron-capture detection with picomole sensitivity. J Chromatogr B Biomed Appl 658:233-40

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