The research hypothesis is that a mechanical property of the upper airway, specifically the elasticity (compliance) of the pharyngeal passage, is responsible for the initiation of upper airway obstruction during sleep. The objectives are a) to determine basic patterns of upper airway and chest wall muscle action which regulates upper airway patency, b) to measure the effects of passive (non-muscular) and dynamic (muscular) factors on upper airway size and compliance, and c) to assess the usefulness of tests of muscle activity and mechanical function in predicting the site of upper airway obstruction during sleep. Methods to be used include standard measurements, such as EMG activity and flow-volume loops, and new tools, such as NMR and acoustic pulse imaging in determining the function of the upper airway under static and dynamic conditions. Studies will be performed during wakefulness and, when appropriate, during sleep. Results from studies on patients and their families will be compared to findings in healthy subjects to identify traits responsible for upper airway obstruction during sleep. Population studies will assess the results from these physiologic studies. The career development goals are to continue extensive involvement in current research awards and to extend my education into new fields (genetic epidemiology, mucosal secretion, and airway microvasculature) relevant to future research. The RCDA award will provide and not merely replace salary support for the remaining years of the proposed studies and for one other, newly funded project, as well as provide support for time to learn and apply new techniques. Thus, this award will facilitate and promote my career toward the long-term goal of leading an academic section in pulmonary medicine.
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| Decker, M J; Arnold, J L; Haney, D et al. (1992) Extended monitoring of oxygen saturation in chronic lung disease. Chest 102:1075-9 |
| Thomas, A J; Austin, W; Friedman, L et al. (1992) A model of ventilatory instability induced in the unrestrained rat. J Appl Physiol 73:1530-6 |
| Strohl, K P; Arnold, J L; Decker, M J et al. (1992) The nasal response to exercise in patients with cystic fibrosis. Rhinology 30:241-8 |
| Beall, C M; Worthman, C M; Stallings, J et al. (1992) Salivary testosterone concentration of Aymara men native to 3600 m. Ann Hum Biol 19:67-78 |
| Haxhiu, M A; Cherniack, N S; Strohl, K P (1991) Reflex responses of laryngeal and pharyngeal submucosal glands in dogs. J Appl Physiol 71:1669-73 |
| Miller, M J; DiFiore, J M; Strohl, K P et al. (1991) Effects of CO2 rebreathing on pulmonary mechanics in premature infants. J Appl Physiol 70:2582-6 |
| Cahan, C; Decker, M; Strohl, K P (1990) Humoral correlates of sleep apnea: erythropoietin and hypoxemia. Prog Clin Biol Res 345:317-22;discussion 323-4 |
| Decker, M J; Dickensheets, D; Arnold, J L et al. (1990) A comparison of a new reflectance oximeter with the Hewlett-Packard ear oximeter. Biomed Instrum Technol 24:122-6 |
| Miller, M J; DiFiore, J M; Strohl, K P et al. (1990) Effects of nasal CPAP on supraglottic and total pulmonary resistance in preterm infants. J Appl Physiol 68:141-6 |
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