Relatively little is known regarding the neuropsychological changes associated with multiple sclerosis (MS). It is the intent of the five year project to define the cognitive and affective disturbance observed in patients with this demyelinating disease. Two groups of patients, MS (N=156) and neurological controls (N=60), will be randomly selected from a large representative patient pool and matched on the basis of age, education, occupation, sex and race. All subjects will be administered a battery of cognitive and affective psychometric tests, and will undergo a neurological examination (including measures of disability), magnetic resonance (MR) imaging, an examination of activities of daily living (ADL), and an assessment of educational/vocational activities. Sixty MS patients and all control patients will be re-evaluated after a three year interval. The objective of this project are: (1) to determine the prevalence, type and severity of cognitive and affective disturbance in a large representative sample of patients with MS, (2) to examine the natural history of cognitive and affective disturbances in MS over a three year retest interval, (3) to identify the behavioral correlates of cerebral plaques and ventricular dilatation, as identified by MR imaging, (4) to assess the effects of cognitive and affective disturbance on ADL and educational/vocational activities, (5) to develop and validate a brief screening instrument to identify MS patients with cognitive disturbance, and (6) to study the relationship between cognitive and affective disturbance in MS.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Modified Research Career Development Award (K04)
Project #
5K04NS001055-04
Application #
3074892
Study Section
Neurology A Study Section (NEUA)
Project Start
1986-12-01
Project End
1991-11-30
Budget Start
1989-12-01
Budget End
1990-11-30
Support Year
4
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Medical College of Wisconsin
Department
Type
Schools of Medicine
DUNS #
073134603
City
Milwaukee
State
WI
Country
United States
Zip Code
53226
Nyenhuis, D L; Luchetta, T; Yamamoto, C et al. (1998) The development, standardization, and initial validation of the Chicago Multiscale Depression Inventory. J Pers Assess 70:386-401
Rao, S M (1996) White matter disease and dementia. Brain Cogn 31:250-68
Rao, S M (1995) Neuropsychology of multiple sclerosis. Curr Opin Neurol 8:216-20
Nyenhuis, D L; Rao, S M; Zajecka, J M et al. (1995) Mood disturbance versus other symptoms of depression in multiple sclerosis. J Int Neuropsychol Soc 1:291-6
Arnett, P A; Rao, S M; Bernardin, L et al. (1994) Relationship between frontal lobe lesions and Wisconsin Card Sorting Test performance in patients with multiple sclerosis. Neurology 44:420-5
Rao, S M; Huber, S J; Bornstein, R A (1992) Emotional changes with multiple sclerosis and Parkinson's disease. J Consult Clin Psychol 60:369-78
Rao, S M; Leo, G J; Bernardin, L et al. (1991) Cognitive dysfunction in multiple sclerosis. I. Frequency, patterns, and prediction. Neurology 41:685-91
Rao, S M; Leo, G J; Ellington, L et al. (1991) Cognitive dysfunction in multiple sclerosis. II. Impact on employment and social functioning. Neurology 41:692-6
Grafman, J; Rao, S; Bernardin, L et al. (1991) Automatic memory processes in patients with multiple sclerosis. Arch Neurol 48:1072-5
Peyser, J M; Rao, S M; LaRocca, N G et al. (1990) Guidelines for neuropsychological research in multiple sclerosis. Arch Neurol 47:94-7

Showing the most recent 10 out of 16 publications