Alcohol abuse and dependence are significant public health problems in the U.S. and worldwide. Clarifying the causes for onset and chronicity of these problems is a high scientific priority, as is the development of practical, effective interventions. This is an application for a K05 Research Scientist Award for Deborah Hasin, Ph.D. The purpose is to provide 5 years of ongoing support for Dr. Hasin to continue and expand her leadership role in alcoholism research. This will be achieved through the K05 release from teaching and administrative duties, allowing Dr. Hasin to continue to concentrate on her research and mentoring, which is characterized by a very high level of scientific accomplishment and productivity. During the K05 award, Dr. Hasin proposes to continue her research program at Columbia University (Mailman School of Public Health, Department of Epidemiology and College of Physicians and Surgeons, Department of Psychiatry). Dr. Hasin's research has focused on four main areas. (1) The validity of concepts of alcohol use disorders in the general population and the natural history of those disorders. (2) The relationship of major depression to alcohol and drug use disorders. Dr. Hasin's work has answered some of the main questions in these two areas, and continues to address important remaining issues. (3) Gene-environment interaction. Israeli population subgroups differ in their exposures to drinking environments and in their drinking. By studying alcohol metabolizing genes, alcohol consumption, and dependence severity in recent Russian immigrants to Israel and other Israelis, Dr. Hasin has identified a unique opportunity to study specific genes under sharply contrasting environmental circumstances (background per capita alcohol consumption levels). Dr. Hasin's work in this area has been described as critical for future directions in gene-environment studies of alcohol. Dr. Hasin will also continue to develop a newer area. (4) Brief intervention for unsafe drinking among patients in HIV primary care. Dr. Hasin will conduct her multifaceted program of research with experts at Columbia University and elsewhere. The K05 plan also includes continued participation in national and international scientific activities, and expansion of Dr. Hasin's mentoring and science education. By releasing Dr. Hasin from other responsibilities, the K05 award will allow Dr. Hasin to maintain her outstanding level of contribution to the field of alcoholism research.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Scientist Award (K05)
Project #
5K05AA014223-10
Application #
8321618
Study Section
Health Services Research Review Subcommittee (AA)
Program Officer
Breslow, Rosalind
Project Start
2003-07-01
Project End
2013-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
10
Fiscal Year
2012
Total Cost
$158,694
Indirect Cost
$11,755
Name
Columbia University (N.Y.)
Department
Psychiatry
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Elliott, Jennifer C; Hasin, Deborah S; Stohl, Malka et al. (2016) HIV, Hepatitis C, and Abstinence from Alcohol Among Injection and Non-injection Drug Users. AIDS Behav 20:548-54
Elliott, Jennifer C; Delker, Erin; Wall, Melanie M et al. (2016) The Importance of Context: Neighborhood Drinking Norms and Heavy Drinking Among HIV Patients. J Acquir Immune Defic Syndr 72:e55-7
Elliott, Jennifer C; Stohl, Malka; Wall, Melanie M et al. (2016) Childhood maltreatment, personality disorders and 3-year persistence of adult alcohol and nicotine dependence in a national sample. Addiction 111:913-23
King, Andrea C; Hasin, Deborah; O'Connor, Sean J et al. (2016) A Prospective 5-Year Re-examination of Alcohol Response in Heavy Drinkers Progressing in Alcohol Use Disorder. Biol Psychiatry 79:489-98
Kerridge, Bradley T; Saha, Tulshi D; Hasin, Deborah S (2016) Armed Conflict, Substance Use and HIV: A Global Analysis. AIDS Behav 20:473-83
Walsh, Kate; Hasin, Deborah; Keyes, Katherine M et al. (2016) Associations between gender-based violence and personality disorders in U.S. women. Personal Disord 7:205-10
Shmulewitz, Dvora; Meyers, Jacquelyn L; Wall, Melanie M et al. (2016) CHRNA5/A3/B4 Variant rs3743078 and Nicotine-Related Phenotypes: Indirect Effects Through Nicotine Craving. J Stud Alcohol Drugs 77:227-37
Talati, A; Keyes, K M; Hasin, D S (2016) Changing relationships between smoking and psychiatric disorders across twentieth century birth cohorts: clinical and research implications. Mol Psychiatry 21:464-71
Kerridge, Bradley T; Tran, Phu; Hasin, Deborah S (2015) Intoxication at last sexual intercourse and unprotected sex among HIV-positive and HIV-negative individuals in Uganda: an event-level analysis. AIDS Behav 19:412-21
Grant, Bridget F; Goldstein, Rise B; Smith, Sharon M et al. (2015) The Alcohol Use Disorder and Associated Disabilities Interview Schedule-5 (AUDADIS-5): reliability of substance use and psychiatric disorder modules in a general population sample. Drug Alcohol Depend 148:27-33

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