This K05 application requests 5 years of support to allow the PI to commit protected time and effort to his research and mentoring program focused on gene-environment interplay and risk-mechanisms in alcoholism, freeing him from the encroachment of administrative responsibilities. The Pi's mentoring will engage 4 junior faculty in the pursuit of independence as NIAAA-funded R01 investigators, in the substantive areas of (i) offspring environmental risks and socioemotional problems associated with parental alcoholism, and comorbidity during the toddler and preschool years, (ii) etiology of very early-onset alcohol and other substance use, with a particular focus on risk-mechanisms associated with parental divorce/never marriage, (iii) transitions in alcohol use and problems from adolescence through young adulthood, particularly the impact of childhood assaultive trauma, and (iv) personal and offspring outcomes, and risk-factors, associated with remission versus recovery of alcohol problems in women with recurrent drunk driving. These diverse research areas are well-matched with the Pi's long-standing interests in (i) alcoholism in women, and (ii) the environmental contexts in which the genetic transmission of alcoholism risk occurs. Additionally, the PI will continue his contributions to the alcoholism field through R01-supported projects which involve (i) follow-up at age 30 of MOAFTS, a birth cohort of female like-sex twin pairs followed from median age 15 to identify mediators and moderators of genetic influences on onset of and recovery from versus persistence in alcohol problems;(ii) continued follow-up of the Australian Children-of-Twins cohorts, contrasting outcomes associated with maternal or paternal alcoholism (high environmental risk, high genetic risk) versus alcoholism only in parent's MZ co-twin (reduced environmental risk, high genetic risk), or DZ co-twin (intermediate genetic risk) and controls;and (iii) methodologic contributions and secondary data-analyses that take advantage of the coordinated assessments, and informativeness about environmental and gene environmental interplay mechanisms, of studies in the Australian twin register and MOAFTS (including the availability of ATR genome-wide association data on 4000 individuals). Understanding environmental contexts for the genetic inheritance of alcoholism should improve both understanding of how to identify and intervene with groups at high-risk for problems, and gene-discovery.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Scientist Award (K05)
Project #
5K05AA017688-02
Application #
7923059
Study Section
Special Emphasis Panel (ZAA1-CC (12))
Program Officer
Scott, Marcia S
Project Start
2008-09-05
Project End
2013-08-31
Budget Start
2009-09-01
Budget End
2010-08-31
Support Year
2
Fiscal Year
2009
Total Cost
$184,490
Indirect Cost
Name
Washington University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Colodro-Conde, L; Sánchez-Romera, J F; Lind, P A et al. (2018) No evidence of association of oxytocin polymorphisms with breastfeeding in 2 independent samples. Genes Brain Behav 17:e12464
Trela, Constantine J; Hayes, Alexander W; Bartholow, Bruce D et al. (2018) Moderation of alcohol craving reactivity to drinking-related contexts by individual differences in alcohol sensitivity: An ecological investigation. Exp Clin Psychopharmacol 26:354-365
Whitfield, John B; Heath, Andrew C; Madden, Pamela A F et al. (2018) Effects of high alcohol intake, alcohol-related symptoms and smoking on mortality. Addiction 113:158-166
Bender, Annah K; Bucholz, Kathleen K; Heath, Andrew C et al. (2018) Comparison of Characteristics of Female Drivers with Single and Multiple DUI Convictions. Alcohol Clin Exp Res 42:646-653
Agrawal, A; Chou, Y-L; Carey, C E et al. (2018) Genome-wide association study identifies a novel locus for cannabis dependence. Mol Psychiatry 23:1293-1302
Micalizzi, Lauren; Marceau, Kristine; Brick, Leslie A et al. (2018) Inhibitory control in siblings discordant for exposure to maternal smoking during pregnancy. Dev Psychol 54:199-208
Sartor, Carolyn E; Grant, Julia D; Few, Lauren R et al. (2018) Childhood Trauma and Two Stages of Alcohol Use in African American and European American Women: Findings from a Female Twin Sample. Prev Sci 19:795-804
Walters, Raymond K; Polimanti, Renato; Johnson, Emma C et al. (2018) Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders. Nat Neurosci 21:1656-1669
Werner, Kimberly B; Cunningham-Williams, Renee M; Sewell, Whitney et al. (2018) The Impact of Traumatic Experiences on Risky Sexual Behaviors in Black and White Young Adult Women. Womens Health Issues 28:421-429
Waldron, Mary; Watkins, Nicole K; Bucholz, Kathleen K et al. (2018) Interactive Effects of Maternal Alcohol Problems and Parental Separation on Timing of Daughter's First Drink. Alcohol Clin Exp Res 42:120-127

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