This K05 application requests 5 years of support to allow the PI to commit protected time and effort to his research and mentoring program focused on gene-environment interplay and risk-mechanisms in alcoholism, freeing him from the encroachment of administrative responsibilities. The Pi's mentoring will engage 4 junior faculty in the pursuit of independence as NIAAA-funded R01 investigators, in the substantive areas of (i) offspring environmental risks and socioemotional problems associated with parental alcoholism, and comorbidity during the toddler and preschool years, (ii) etiology of very early-onset alcohol and other substance use, with a particular focus on risk-mechanisms associated with parental divorce/never marriage, (iii) transitions in alcohol use and problems from adolescence through young adulthood, particularly the impact of childhood assaultive trauma, and (iv) personal and offspring outcomes, and risk-factors, associated with remission versus recovery of alcohol problems in women with recurrent drunk driving. These diverse research areas are well-matched with the Pi's long-standing interests in (i) alcoholism in women, and (ii) the environmental contexts in which the genetic transmission of alcoholism risk occurs. Additionally, the PI will continue his contributions to the alcoholism field through R01-supported projects which involve (i) follow-up at age 30 of MOAFTS, a birth cohort of female like-sex twin pairs followed from median age 15 to identify mediators and moderators of genetic influences on onset of and recovery from versus persistence in alcohol problems;(ii) continued follow-up of the Australian Children-of-Twins cohorts, contrasting outcomes associated with maternal or paternal alcoholism (high environmental risk, high genetic risk) versus alcoholism only in parent's MZ co-twin (reduced environmental risk, high genetic risk), or DZ co-twin (intermediate genetic risk) and controls;and (iii) methodologic contributions and secondary data-analyses that take advantage of the coordinated assessments, and informativeness about environmental and gene environmental interplay mechanisms, of studies in the Australian twin register and MOAFTS (including the availability of ATR genome-wide association data on 4000 individuals). Understanding environmental contexts for the genetic inheritance of alcoholism should improve both understanding of how to identify and intervene with groups at high-risk for problems, and gene-discovery.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Scientist Award (K05)
Project #
5K05AA017688-05
Application #
8321077
Study Section
Special Emphasis Panel (ZAA1-CC (12))
Program Officer
Scott, Marcia S
Project Start
2008-09-05
Project End
2013-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
5
Fiscal Year
2012
Total Cost
$184,490
Indirect Cost
$13,666
Name
Washington University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Munn-Chernoff, Melissa A; Grant, Julia D; Agrawal, Arpana et al. (2015) Are there common familial influences for major depressive disorder and an overeating-binge eating dimension in both European American and African American female twins? Int J Eat Disord 48:375-82
Loukola, A; Wedenoja, J; Keskitalo-Vuokko, K et al. (2014) Genome-wide association study on detailed profiles of smoking behavior and nicotine dependence in a twin sample. Mol Psychiatry 19:615-24
Agrawal, Arpana; Madden, Pamela A F; Bucholz, Kathleen K et al. (2014) Initial reactions to tobacco and cannabis smoking: a twin study. Addiction 109:663-71
Koren, Rachel; Duncan, Alexis E; Munn-Chernoff, Melissa A et al. (2014) Preliminary evidence for the role of HTR2A variants in binge eating in young women. Psychiatr Genet 24:28-33
Pergadia, Michele L; Der-Avakian, Andre; D'Souza, Manoranjan S et al. (2014) Association between nicotine withdrawal and reward responsiveness in humans and rats. JAMA Psychiatry 71:1238-45
Heath, Andrew C; Waldron, Mary C; Martin, Nicholas G et al. (2014) Human mate selection and addiction: a conceptual critique. Behav Genet 44:419-26
van den Berg, St├ęphanie M; de Moor, Marleen H M; McGue, Matt et al. (2014) Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory. Behav Genet 44:295-313
Waldron, Mary; Vaughan, Ellen L; Bucholz, Kathleen K et al. (2014) Risks for early substance involvement associated with parental alcoholism and parental separation in an adolescent female cohort. Drug Alcohol Depend 138:130-6
Power, R A; Verweij, K J H; Zuhair, M et al. (2014) Genetic predisposition to schizophrenia associated with increased use of cannabis. Mol Psychiatry 19:1201-4
McCutcheon, Vivia V; Kramer, John R; Edenberg, Howard J et al. (2014) Social contexts of remission from DSM-5 alcohol use disorder in a high-risk sample. Alcohol Clin Exp Res 38:2015-23

Showing the most recent 10 out of 69 publications