This is a new application for a Senior Scientist Research and Mentorship Award (K05). The applicant, Michael Windle, Rollins Endowed Professor of Public Health and Chair of the Department of Behavioral Sciences and Health Education (BSHE) at Emory University, proposes to provide mentoring to three outstanding tenure-track faculty members. Two of the applicants to be mentored are assistant professors in BSHE, and the third is from a nearby university and has been mentored by the applicant for the last three-years. All three of these mentees have excellent publication records, have published studies on alcohol and other substance use, have demonstrated interest in pursuing NIAAA R01 awards, and none has received funding at the R01 level. Two of the mentees currently have K01 awards. All three mentees have an interest in developing further their knowledge of alcohol studies, the use of advanced longitudinal statistical methods in their research, and the incorporation gene-environment (GE) relations as they prepare NIH applications. For all applicants, mentoring goals involve providing guidance and support with respect to writing competitive grant proposals, further developing the mentees'research programs, and a further focus on more general professional development, including working with mentees on their own effectiveness as mentors to graduate students and postdoctoral trainees. With respect to his Research Plan, the applicant proposes to continue to pursue a research program that applies a lifespan developmental psychopathology perspective in alcohol studies with particular emphasis on understanding stability and change in alcohol use and alcohol disorders across the lifespan (e.g., changes associated with transitions from adolescence to emerging adulthood to young adulthood;changes from middle-age to older adulthood), transitions in drinking status across time (e.g., light drinker to heavy drinker;heavy drinker to light drinker or abstainer), and the tme invariant and time-varying risk and protective predictors of these changes across the life course. Using several existing and ongoing longitudinal data sets, the applicant proposes to continue research on the developmental- etiologic factors that influence alcohol phenotypes across time and for different racial/ethnic groups. Specific emphasis is focused on the analyses of prospective panel data and GE relations that provide novel opportunities to study prominent developmental processes related to alcohol phenotypes in a highly refined and nuanced way that incorporates both G and E factors and their interactions as they unfold across time. Alcohol prevention programs for public health are best guided by models that ncorporate the time-changing, multiplicity of genetic (G), environmental (E) factors that underlie the etiology and time-course of alcohol misuse and alcohol disorders. A new generation of mentored scientists with the necessary skills to conduct such analyses could rapidly advance the alcohol studies field and greatly facilitate efforts to reduce underage drinking and associated adverse health consequences across the lifespan.

Public Health Relevance

Epidemiologic findings with national samples have indicated that the peak period of alcohol dependence is during late adolescence-early young adulthood (ages 18-22). These findings have resulted in a revision of conceptual models of alcohol use and alcohol disorders away from soley reductionistic models (e.g., physiological determinants) toward developmental, multilevel models. This K05 application proposes to use multiple longitudinal datasets to examine multilevel influences, including gene-environment interactions, to study stability and change in alcohol use and alcohol disorders across the lifespan.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Research Scientist Award (K05)
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Health Services Research Review Subcommittee (AA)
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Ruffin, Beverly
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Emory University
Schools of Public Health
United States
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Windle, Michael (2016) Don't throw away the champagne with the cork-age at first drink revisited. Addiction 111:966-7
Windle, Michael (2016) Drinking Over the Lifespan: Focus on Early Adolescents and Youth. Alcohol Res 38:95-101
Windle, Michael; Kogan, Steven M; Lee, Sunbok et al. (2016) Neighborhood × Serotonin Transporter Linked Polymorphic Region (5-HTTLPR) interactions for substance use from ages 10 to 24 years using a harmonized data set of African American children. Dev Psychopathol 28:415-31
Haardörfer, Regine; Berg, Carla J; Lewis, Michael et al. (2016) Polytobacco, marijuana, and alcohol use patterns in college students: A latent class analysis. Addict Behav 59:58-64
Berg, Carla J; Romero, Devan R; Pulvers, Kim (2015) Perceived harm of tobacco products and individual schemas of a smoker in relation to change in tobacco product use over one year among young adults. Subst Use Misuse 50:90-8
Windle, Michael; Windle, Rebecca C (2015) A prospective study of stressful events, coping motives for drinking, and alcohol use among middle-aged adults. J Stud Alcohol Drugs 76:465-73
Sun, Li; Windle, Michael; Thompson, Nancy J (2015) An Exploration of the Four-Factor Structure of the Drinking Motives Questionnaire-Revised Among Undergraduate Students in China. Subst Use Misuse 50:1590-8
Windle, Michael; Wiesner, Margit; Elliott, Marc N et al. (2015) The Abbreviated Dimensions of Temperament Survey: Factor Structure and Construct Validity Across Three Racial/Ethnic Groups. J Pers Assess 97:515-24
Berg, Carla J; Stratton, Erin; Schauer, Gillian L et al. (2015) Perceived harm, addictiveness, and social acceptability of tobacco products and marijuana among young adults: marijuana, hookah, and electronic cigarettes win. Subst Use Misuse 50:79-89
Wiesner, Margit; Windle, Michael; Kanouse, David E et al. (2015) DISC Predictive Scales (DPS): Factor structure and uniform differential item functioning across gender and three racial/ethnic groups for ADHD, conduct disorder, and oppositional defiant disorder symptoms. Psychol Assess 27:1324-36

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