The K05 application for Barbara L. Andersen is submitted to enable a full time effort in cancer control research and mentoring. She is a professor in the Department of Psychology and a member of the Cancer Prevention and Control and the Immunology programs of the Comprehensive Cancer Center at the Ohio State University. A Biobehavioral Model of cancer stress and disease course (Andersen et al., 1994) provides a conceptual framework for the current research (CA92704, 7/01/01-6/30/06). The model includes psychological (stress and quality of life), behavioral (health behaviors and compliance), and biologic (endocrine and immune) factors and specifies the pathways for effects on health. A randomized clinical trial with breast cancer patients tests components of the model and efficacy of a psychological intervention. The research yields novel biobehavioral data, and the study is poised to experimentally test disease endpoint hypotheses. The K05 research goal is to extend the biobehavioral approach to the context of cancer recurrence. Despite its clinical importance, cancer recurrence has received little systematic study. The proposed controlled, prospective, longitudinal design has powerful methodological and scientific advantages, would yield unique data, and test related hypotheses of the R01 trial. Since the previous submission, the recurrence study has been funded (RSGPB-03-248; 7/1/03-6/30/08). The KO5 mentoring goal would continue Andersen's successful record during the past 20+ years of mentoring pre and postdoctoral trainees. She admits students with exceptional academic records who become trainee-collaborators in her interdisciplinary cancer control research. Enhanced mentoring is proposed to increase the trainees' level of professional maturity, enhance their scholarly record, and facilitate the transition of the 'best and the brightest' to careers as independent investigators and leaders in cancer prevention and control.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Scientist Award (K05)
Project #
5K05CA098133-02
Application #
6945426
Study Section
Subcommittee G - Education (NCI)
Program Officer
Lohrey, Nancy
Project Start
2004-09-01
Project End
2009-07-31
Budget Start
2005-08-01
Budget End
2006-07-31
Support Year
2
Fiscal Year
2005
Total Cost
$146,427
Indirect Cost
Name
Ohio State University
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210
Ryba, Marlena M; Brothers, Brittany M; Andersen, Barbara L (2017) Implementation of an evidence-based biobehavioral treatment for cancer patients. Transl Behav Med 7:648-656
Andersen, Barbara L; Goyal, Neha Godiwala; Westbrook, Travis D et al. (2017) Trajectories of Stress, Depressive Symptoms, and Immunity in Cancer Survivors: Diagnosis to 5 Years. Clin Cancer Res 23:52-61
Morrison, Eleshia J; Flynn, Joseph M; Jones, Jeffrey et al. (2016) Individual differences in physical symptom burden and psychological responses in individuals with chronic lymphocytic leukemia. Ann Hematol 95:1989-1997
Westbrook, Travis D; Maddocks, Kami; Andersen, Barbara L (2016) The relation of illness perceptions to stress, depression, and fatigue in patients with chronic lymphocytic leukaemia. Psychol Health 31:891-902
Andersen, Barbara L; Dorfman, Caroline S (2016) Evidence-based psychosocial treatment in the community: considerations for dissemination and implementation. Psychooncology 25:482-90
Conley, Claire C; Bishop, Brenden T; Andersen, Barbara L (2016) Emotions and Emotion Regulation in Breast Cancer Survivorship. Healthcare (Basel) 4:
Lutgendorf, Susan K; Andersen, Barbara L (2015) Biobehavioral approaches to cancer progression and survival: Mechanisms and interventions. Am Psychol 70:186-97
Williams, Kristen C; Brothers, Brittany M; Ryba, Marlena M et al. (2015) Implementing evidence-based psychological treatments for cancer patients. Psychooncology 24:1618-25
Wu, Salene M; Yang, Hae-Chung; Thayer, Julian F et al. (2014) Association of the physiological stress response with depressive symptoms in patients with breast cancer. Psychosom Med 76:252-6
Thornton, Lisa M; Levin, Anna O; Dorfman, Caroline S et al. (2014) Emotions and social relationships for breast and gynecologic patients: a qualitative study of coping with recurrence. Psychooncology 23:382-9

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