This K05 grant will provide training, educational, and research experiences that allow Dr. Timothy Baker to perform groundbreaking research, both transdisciplinary and translational, on tobacco use and other addictive disorders. Specifically, the research will foster the integration of theories, data, and methods from diverse disciplines and among many collaborators. In addition, it will permit him to conduct translational research in which innovative basic science models and methods are used to generate new treatments and assessments;viz. to facilitate the transfer of basic science findings and perspectives so that they achieve more effective real-world application. The requested support also will facilitate Dr. Baker's teaching and training of the future cadre of addiction scientists, especially physicians-in-training. To accomplish these aims, the applicant will: (1) use the requested support to reduce his administrative and teaching obligations;(2) take classes, engage in intensive reading and study, and consult with experts in targeted areas of special relevance to the applicant's research;(3) design and conduct new research studies that provide outstanding opportunity for transdisciplinary and translational research addressing tobacco use and other addictive disorders;and, (4) conduct on-going theory and methods training seminars and serve as a research mentor, with these efforts aimed especially at physicians-in-training. The proposed work will benefit from the tremendous resources available in the applicant's research environment and by his on-going research with a large transdisciplinary team. This K05 grant should benefit public health by enhancing the quality of research on addictive disorders performed by Dr. Baker, his collaborators, and those he trains. Specifically, this support should promote better understanding of tobacco use and other addictive disorders and, ultimately, impact the health of the nation by producing more effective treatments for these devastating, diseases.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Scientist Award (K05)
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Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Perkins, Susan N
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University of Wisconsin Madison
Schools of Arts and Sciences
United States
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Teitelbaum, A M; Murphy, S E; Akk, G et al. (2017) Nicotine dependence is associated with functional variation in FMO3, an enzyme that metabolizes nicotine in the brain. Pharmacogenomics J :
Piper, Megan E; Cook, Jessica W; Schlam, Tanya R et al. (2017) Toward precision smoking cessation treatment II: Proximal effects of smoking cessation intervention components on putative mechanisms of action. Drug Alcohol Depend 171:50-58
Piper, Megan E; Schlam, Tanya R; Cook, Jessica W et al. (2017) Toward precision smoking cessation treatment I: Moderator results from a factorial experiment. Drug Alcohol Depend 171:59-65
Chen, Li-Shiun; Baker, Timothy; Brownson, Ross C et al. (2017) Smoking Cessation and Electronic Cigarettes in Community Mental Health Centers: Patient and Provider Perspectives. Community Ment Health J 53:695-702
Cook, Jessica W; Baker, Timothy B; Beckham, Jean C et al. (2017) Smoking-induced affect modulation in nonwithdrawn smokers with posttraumatic stress disorder, depression, and in those with no psychiatric disorder. J Abnorm Psychol 126:184-198
Baker, Timothy B; Smith, Stevens S; Bolt, Daniel M et al. (2017) Implementing Clinical Research Using Factorial Designs: A Primer. Behav Ther 48:567-580
Baker, Timothy B; Collins, Linda M; Mermelstein, Robin et al. (2016) Enhancing the effectiveness of smoking treatment research: conceptual bases and progress. Addiction 111:107-16
Cook, Jessica W; Collins, Linda M; Fiore, Michael C et al. (2016) Comparative effectiveness of motivation phase intervention components for use with smokers unwilling to quit: a factorial screening experiment. Addiction 111:117-28
Baker, Timothy B; Piper, Megan E; Stein, James H et al. (2016) Effects of Nicotine Patch vs Varenicline vs Combination Nicotine Replacement Therapy on Smoking Cessation at 26 Weeks: A Randomized Clinical Trial. JAMA 315:371-9
Schlam, Tanya R; Fiore, Michael C; Smith, Stevens S et al. (2016) Comparative effectiveness of intervention components for producing long-term abstinence from smoking: a factorial screening experiment. Addiction 111:142-55

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