The K05 candidate is a senior faculty member (professor) who has been actively involved in cancer research and mentoring for over two decades. She is an independent investigator who has developed and sustained a vigorous research and training program in cancer prevention. The candidate has over 270 scientific publications and is recognized nationally and internationally for her prostate cancer (PCa) research (e.g., epidemiology, biomarkers, prevention, outcomes). The candidate's research program has been instrumental in building a robust environment and infrastructure that will provide critical support, resources, and opportunities for young investigators during the proposed K05 award. This award would provide needed support for the candidate to devote substantially more time and effort toward career development goals and successful launching of the next generation of young investigators in cancer prevention. The K05 proposal has 3 components: 1) Career Plan;2) Research Plan;and, 3) Mentoring Plan. Dr. Stanford's Career Plan includes: 1) advancing knowledge of genomics, epigenomics, and molecular biology;2) augmenting her research skills, particularly related to analyses of high-throughput data;and, 3) enhancing her mentoring skills. The career plan is strongly tied to the proposed research and mentoring plans, and will encompass academic courses, conferences, heading a new journal club, and teaching in the research ethics program. The Research Plan is aimed to expand knowledge of biomarkers for PCa, and will test the hypothesis that epigenomic and genetic alterations influence PCa progression to its aggressive phenotype. The research plan will: 1) determine whether genome-wide DNA methylation and gene expression profiles in PCa tumor tissue are associated with recurrent and lethal PCa;and, 2) combine top-ranked genes from the methylation and expression profiles with genetic variants associated with PCa-specific mortality to build an integrated panel of biomarkers for stratification of patients (indolent vs. aggressive tumors) who may benefit most from novel therapy and prevention approaches. The research plan will take advantage of a population-based cohort of PCa patients (n=1,458) with available data and biospecimens. The Mentoring Plan is built upon the candidate's experience gained from working with graduate students, fellows, and junior faculty, and will include both individual and group interactions aimed at inspiring and building the research and career skills of K05 mentees (e.g., study design and methodology, data analyses, writing scientific papers and grant proposals, presenting at scientific meetings). Trainees will be identified and supported through training and other grants and awards within the candidate's research-academic environment. All data, biospecimens, and resources from the candidate's research program will be made available for training these young scientists.

Public Health Relevance

The K05 proposal involves career development, research, and mentoring plans that are clearly tied together for synergy and to meet the overall goal of advancing the candidate's career and mentoring skills for training the next generation of young researchers in cancer prevention and control. The research plan focuses on epigenomic and genetic biomarkers for aggressive prostate cancer (PCa). The intellectual ability and research expertise that these young, well-trained investigators will bring to the fight against PCa, which i a major cause of human suffering and death, may lead to development of novel therapy and prevention approaches.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Scientist Award (K05)
Project #
1K05CA175147-01A1
Application #
8635188
Study Section
Subcommittee G - Education (NCI)
Program Officer
Perkins, Susan N
Project Start
2014-01-09
Project End
2018-12-31
Budget Start
2014-01-09
Budget End
2014-12-31
Support Year
1
Fiscal Year
2014
Total Cost
$88,959
Indirect Cost
$6,590
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
078200995
City
Seattle
State
WA
Country
United States
Zip Code
98109
Wright, J L; Chéry, L; Holt, S et al. (2016) Aspirin and NSAID use in association with molecular subtypes of prostate cancer defined by TMPRSS2:ERG fusion status. Prostate Cancer Prostatic Dis 19:53-6
Zhao, Shanshan; Geybels, Milan S; Leonardson, Amy et al. (2016) Epigenome-Wide Tumor DNA Methylation Profiling Identifies Novel Prognostic Biomarkers of Metastatic-Lethal Progression in Men Diagnosed with Clinically Localized Prostate Cancer. Clin Cancer Res :
Rubicz, Rohina; Zhao, Shanshan; Geybels, Milan et al. (2016) DNA methylation profiles in African American prostate cancer patients in relation to disease progression. Genomics :
Shui, Irene M; Wong, Chao-Jen; Zhao, Shanshan et al. (2016) Prostate tumor DNA methylation is associated with cigarette smoking and adverse prostate cancer outcomes. Cancer 122:2168-77
Shui, Irene M; Kolb, Suzanne; Hanson, Christi et al. (2016) Trichomonas vaginalis infection and risk of advanced prostate cancer. Prostate 76:620-3
Geybels, Milan S; Zhao, Shanshan; Wong, Chao-Jen et al. (2015) Epigenomic profiling of DNA methylation in paired prostate cancer versus adjacent benign tissue. Prostate 75:1941-50
Penney, K L; Shui, I M; Feng, Z et al. (2015) Replication of a genetic variant for prostate cancer-specific mortality. Prostate Cancer Prostatic Dis 18:260-3
Karyadi, Danielle M; Zhao, Shanshan; He, Qianchuan et al. (2015) Confirmation of genetic variants associated with lethal prostate cancer in a cohort of men from hereditary prostate cancer families. Int J Cancer 136:2166-71
Egbers, Lieke; Luedeke, Manuel; Rinckleb, Antje et al. (2015) Obesity and Prostate Cancer Risk According to Tumor TMPRSS2:ERG Gene Fusion Status. Am J Epidemiol 181:706-13
Stott-Miller, Marni; Zhao, Shanshan; Wright, Jonathan L et al. (2014) Validation study of genes with hypermethylated promoter regions associated with prostate cancer recurrence. Cancer Epidemiol Biomarkers Prev 23:1331-9