Abstract

This is a proposal for a Research Scientist Award that would serve as a renewal/replacement of a Research Scientist Development Award that is expiring after 10 years of support. The applicant serves as director of the Behavioral Pharmacology Research Unit at The Johns Hopkins University School of Medicine. That Unit maintains a large and multifaceted research program on the human behavioral pharmacology of substance abuse and is the site of a NIDA Postdoctoral Research Training Program on that topic. The candidate proposes to continue his directorship of the Research Unit and of the research training program and to pursue clinical research on substance abuse in the following areas: 1) Opioid clinical pharmacology; 2) Clinical pharmacology of other abused drugs (sedatives, benzodiazepines, tobacco, caffeine); 3) Behavioral and pharmacological treatment of drug abuse (opioid, polydrug, cocaine); 4) Cigarette smoking.
The aim of the research is to elucidate the determinants and consequences of human drug self-administration and to identify commonalities among and differences between different substance abuse disorders and different types of drug self-administration.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Scientist Award (K05)
Project #
5K05DA000050-14
Application #
3075349
Study Section
Special Emphasis Panel (SRCD (07))
Project Start
1977-12-01
Project End
1992-11-30
Budget Start
1990-12-01
Budget End
1991-11-30
Support Year
14
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Copersino, Marc L; Meade, Christina S; Bigelow, George E et al. (2010) Measurement of self-reported HIV risk behaviors in injection drug users: comparison of standard versus timeline follow-back administration procedures. J Subst Abuse Treat 38:60-5
Rogers, Randall E; Higgins, Stephen T; Silverman, Kenneth et al. (2008) Abstinence-contingent reinforcement and engagement in non-drug-related activities among illicit drug abusers. Psychol Addict Behav 22:544-50
Wedam, Erich F; Bigelow, George E; Johnson, Rolley E et al. (2007) QT-interval effects of methadone, levomethadyl, and buprenorphine in a randomized trial. Arch Intern Med 167:2469-75
Sigmon, Stacey C (2007) Investigating the pharmacological and nonpharmacological factors that modulate drug reinforcement. Exp Clin Psychopharmacol 15:1-20
Sigmon, Stacey C; Moody, David E; Nuwayser, Elie S et al. (2006) An injection depot formulation of buprenorphine: extended bio-delivery and effects. Addiction 101:420-32
Lott, David C; Strain, Eric C; Brooner, Robert K et al. (2006) HIV risk behaviors during pharmacologic treatment for opioid dependence: a comparison of levomethadyl acetate [corrected] buprenorphine, and methadone. J Subst Abuse Treat 31:187-94
Carroll, C Patrick; Walsh, Sharon L; Bigelow, George E et al. (2006) Assessment of agonist and antagonist effects of tramadol in opioid-dependent humans. Exp Clin Psychopharmacol 14:109-20
Donny, Eric C; Bigelow, George E; Walsh, Sharon L (2006) Comparing the physiological and subjective effects of self-administered vs yoked cocaine in humans. Psychopharmacology (Berl) 186:544-52
Lofwall, Michelle R; Brooner, Robert K; Bigelow, George E et al. (2005) Characteristics of older opioid maintenance patients. J Subst Abuse Treat 28:265-72
Donny, Eric C; Brasser, Susan M; Bigelow, George E et al. (2005) Methadone doses of 100 mg or greater are more effective than lower doses at suppressing heroin self-administration in opioid-dependent volunteers. Addiction 100:1496-509

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