A renewal of Research Scientist Development Award (K02), with advancement to the Senior Scientist (K05) level, is requested to allow the candidate to continue to pursue research on behavioral treatments for substance abuse on a full-time basis. As described in the Scientific Autobiography, through adherence to a technology model of psychotherapy research, and with emphasis on development and broader dissemination of these methods and treatments, the candidate's long-term goal is to improve the effectiveness of substance abuse treatment. As described in the Research Plan, during the term of support from the proposed Research Scientist Development Award, the candidate will serve as Principal Investigator on a project to evaluate manual-guided Twelve Step Facilitation and disulfiram as treatment for cocaine-dependence individuals on methadone maintenance: In this 2x2 factorial study, 180 cocaine-dependent methadone-maintained opioid addicts will be assigned to one of four treatments: (1) Twelve-Step Facilitation (TSF) in addition to standard counseling plus disulfiram, (2) Twelve-Step Facilitation (TSF) plus placebo, (3) Standard counseling plus disulfiram, or (4) Standard methadone counseling plus placebo. Study treatments will be manual-guided and will last 12 weeks. The primary outcome will be reduction in cocaine use, as assessed by self-report and confirmed by thrice-weekly urinalyses. Secondary outcomes will include reductions in illicit opioid and alcohol use, as well as improvements in psychosocial functioning. Treatments will be delivered by experienced clinicians, who will receive training and ongoing supervision to prevent drift during the course of the study. Supervised urines will be collected thrice weekly. All counseling sessions will be videotaped for ongoing therapist supervision and process assessment. Follow-ups at 1, 3, 6, 9 and 12 months after cessation of study treatments will assess the durability and/or delayed emergence of treatment effects.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Research Scientist Award (K05)
Project #
Application #
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Riddle, Melissa
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Project End
Budget Start
Budget End
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Fiscal Year
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Yale University
Schools of Medicine
New Haven
United States
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Carroll, Kathleen M; Nich, Charla; Petry, Nancy M et al. (2016) A randomized factorial trial of disulfiram and contingency management to enhance cognitive behavioral therapy for cocaine dependence. Drug Alcohol Depend 160:135-42
Yip, Sarah W; DeVito, Elise E; Kober, Hedy et al. (2016) Anticipatory reward processing among cocaine-dependent individuals with and without concurrent methadone-maintenance treatment: Relationship to treatment response. Drug Alcohol Depend 166:134-42
Samuel, Douglas B; Carroll, Kathleen M; Rounsaville, Bruce J et al. (2013) Personality disorders as maladaptive, extreme variants of normal personality: borderline personality disorder and neuroticism in a substance using sample. J Pers Disord 27:625-35
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DeVito, Elise E; Worhunsky, Patrick D; Carroll, Kathleen M et al. (2012) A preliminary study of the neural effects of behavioral therapy for substance use disorders. Drug Alcohol Depend 122:228-35
Carroll, Kathleen M; Nich, Charla; Lapaglia, Donna M et al. (2012) Combining cognitive behavioral therapy and contingency management to enhance their effects in treating cannabis dependence: less can be more, more or less. Addiction 107:1650-9
Carroll, Kathleen M; Nich, Charla; Shi, Julia M et al. (2012) Efficacy of disulfiram and Twelve Step Facilitation in cocaine-dependent individuals maintained on methadone: a randomized placebo-controlled trial. Drug Alcohol Depend 126:224-31
Jia, Zhiru; Worhunsky, Patrick D; Carroll, Kathleen M et al. (2011) An initial study of neural responses to monetary incentives as related to treatment outcome in cocaine dependence. Biol Psychiatry 70:553-60
Sofuoglu, Mehmet; Waters, Andrew J; Poling, James et al. (2011) Galantamine improves sustained attention in chronic cocaine users. Exp Clin Psychopharmacol 19:11-9
Kiluk, Brian D; Nich, Charla; Carroll, Kathleen M (2011) Relationship of cognitive function and the acquisition of coping skills in computer assisted treatment for substance use disorders. Drug Alcohol Depend 114:169-76

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