The proposed K05 Senior Scientist award renewal will give Professor James C. (Jim) Anthony of Michigan State University (MSU) protected time for a minimum of 75% FTE devoted to NIDA's research mission in relation to three elements of activity. First, continuation of his strong mentorship of early career stage (ECS) and junior investigators at MSU and at other institutions, as well as continued direction of MSU's Drug Dependence Epidemiology Training Program during its anticipated concurrent renewal period. Second, continuation of his 3 current NIDA R01-supported epidemiology/prevention research projects as well as development of new projects of an exploratory/development character, designed to address a serious challenge of study non- participation and sample attrition in recent epidemiology/prevention field studies. Third, continuation of his own career development in relation to topics of central and mutual interest to the ECS and other mentees he will serve (e.g., epidemiology/prevention research in 'drug dependence enviromics') and responsible research training. Here, whereas the 'genome'refers to the total ensemble of genetic material for each life form, the 'envirome'is the total ensemble of environmental processes and circumstances required for life form viability and successful adaptation. In complement with genomics and proteomics, drug dependence enviromics is a deliberate search for specific environmental processes and circumstances that promote health by reducing the risk, prevalence, and problems of drug dependence. In drug dependence enviromics, the main objects of study are neither the gene nor the environment, but rather the gene-environment interactions that give rise to drug dependence, prevent or sustain it, interrupt its natural history, and reduce the global burden of drug dependence and associated disabilities. The long-term goal is definitive evidence on practical population-level public health approaches to the prevention and control of drug dependence processes, from early process steps (e.g., 1st chance to try a drug;1st onset of use) to later steps (e.g., coalescence of drug dependence syndrome, secondary consequences, death by drug overdose or other misadventure), with due attention to cessation of drug use as well.

Public Health Relevance

In drug dependence enviromics research, we seek to discover environmental conditions and processes that drive practical population-level public health prevention and control techniques. For success in public health work, results must be reduced population-level prevalence of drug dependence in complement with clinical work focused on individually tailored plans for patient care (e.g., drug dependence treatment).

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Scientist Award (K05)
Project #
5K05DA015799-10
Application #
8661717
Study Section
AIDS Behavioral Research Subcommittee (NIDA)
Program Officer
Schulden, Jeffrey D
Project Start
2003-09-30
Project End
2016-03-31
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
10
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Michigan State University
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
City
East Lansing
State
MI
Country
United States
Zip Code
48824
Cheng, Hui G; Anthony, James C (2016) A new era for drinking? Epidemiological evidence on adolescent male-female differences in drinking incidence in the United States and Europe. Soc Psychiatry Psychiatr Epidemiol :
Cheng, Hui G; Cantave, Marven D; Anthony, James C (2016) Taking the First Full Drink: Epidemiological Evidence on Male-Female Differences in the United States. Alcohol Clin Exp Res 40:816-25
Alshaarawy, Omayma; Breslau, Naomi; Anthony, James C (2016) Monthly Estimates of Alcohol Drinking During Pregnancy: United States, 2002-2011. J Stud Alcohol Drugs 77:272-6
Vsevolozhskaya, Olga A; Anthony, James C (2016) Transitioning from First Drug Use to Dependence Onset: Illustration of a Multiparametric Approach for Comparative Epidemiology. Neuropsychopharmacology 41:869-76
Anthony, James C; Lopez-Quintero, Catalina; Alshaarawy, Omayma (2016) Cannabis Epidemiology: A Selective Review. Curr Pharm Des :
Forero, Diego A; González-Giraldo, Yeimy; López-Quintero, Catalina et al. (2016) Telomere length in Parkinson's disease: A meta-analysis. Exp Gerontol 75:53-5
Cheng, Hui G; Alshaarawy, Omayma; Cantave, Marven D et al. (2016) Inverse association linking serum levels of potential antioxidant vitamins with C-reactive protein levels using a novel analytical approach. Br J Nutr 116:1256-1264
Cottler, Linda B; Hu, Hui; Smallwood, Bryan A et al. (2016) Nonmedical Opioid Pain Relievers and All-Cause Mortality: A 27-Year Follow-Up From the Epidemiologic Catchment Area Study. Am J Public Health 106:509-16
Alshaarawy, Omayma; Anthony, James C (2016) The replicability of cannabis use prevalence estimates in the United States. Int J Methods Psychiatr Res :
Alshaarawy, Omayma; Elbaz, Hosam A; Andrew, Michael E (2016) The association of urinary polycyclic aromatic hydrocarbon biomarkers and cardiovascular disease in the US population. Environ Int 89-90:174-8

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