The goal of this competing renewal K05 proposal is to continue to support my research in the treatment of nicotine dependence, to further my capacity to mentor junior scientists and train postdoctoral scholars, to allow me to continue in scientific leadership through research center administration, and to disseminate research findings to the scientific and clinical community. Since this award was last submitted, I have published, in press, or under review 62 scientific papers. I completed a clinical trial (N=322) of an innovative intervention for depressed smokers in a psychiatric outpatient clinic, studying both smoking abstinence and its impact on mental health, and the cost-effectiveness of the intervention. As proposed, I am completing two major clinical trials: (1) a study of extended behavioral relapse prevention and bupropion treatment for chronic smokers (N=407);(2) a study of extended, age-specific relapse prevention and nicotine replacement treatment for older smokers (n=403). Extended treatment conditions in these two studies have produced biologically confirmed abstinence rates from 53 to 42% at one year. Of greatest importance, these rates do not change at two year follow-up;they remain at precisely the level observed at one year. I continued to direct a P50 center grant that focuses on Treatment of Complex Patients with an emphasis on nicotine. In addition, I have developed collaborations with other scientists, who are mostly my mentees. This work includes tobacco dependence treatment studies for targeted populations and for co-morbid smokers. In addition, I collaborate with other scientists of the genetics of bupropion response in smokers, and on the effects of reduced nicotine cigarettes. If this award is funded, I will continue my work on extended treatment, studying implementation in health care settings, and developing and testing technology based adaptations of it. I will continue my leadership role in the P50 grant and in the postdoctoral training grant, and will continue to collaborate with other faculty, especially junior faculty. I have a history of mentoring junior faculty that extends back well before the receipt of this award. I will also continue my mentoring role, and increase my mentoring of junior faculty, as new faculty are recruited, and the new departmental mentoring program is implemented and enhanced. Last, I will continue my work with individual postdoctoral trainees.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Scientist Award (K05)
Project #
5K05DA016752-10
Application #
8264225
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Grossman, Debra
Project Start
2003-08-20
Project End
2013-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
10
Fiscal Year
2012
Total Cost
$113,724
Indirect Cost
$8,424
Name
University of California San Francisco
Department
Psychiatry
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Grady, Eric S; Humfleet, Gary L; Delucchi, Kevin L et al. (2014) Smoking cessation outcomes among sexual and gender minority and nonminority smokers in extended smoking treatments. Nicotine Tob Res 16:1207-15
Prochaska, Judith J; Hall, Stephen E; Delucchi, Kevin et al. (2014) Efficacy of initiating tobacco dependence treatment in inpatient psychiatry: a randomized controlled trial. Am J Public Health 104:1557-65
Young-Wolff, Kelly C; Fromont, Sebastien C; Delucchi, Kevin et al. (2014) PTSD symptomatology and readiness to quit smoking among women with serious mental illness. Addict Behav 39:1231-4
Barnett, Paul G; Wong, Wynnie; Jeffers, Abra et al. (2014) Cost-effectiveness of extended cessation treatment for older smokers. Addiction 109:314-22
Hendricks, Peter S; Delucchi, Kevin L; Benowitz, Neal L et al. (2014) Clinical significance of early smoking withdrawal effects and their relationships with nicotine metabolism: preliminary results from a pilot study. Nicotine Tob Res 16:615-20
Hendricks, Peter S; Peters, Erica N; Thorne, Christopher B et al. (2014) Expectancies for smoking cessation among drug-involved smokers: implications for clinical practice. J Subst Abuse Treat 46:320-4
Ramo, Danielle E; Delucchi, Kevin L; Liu, Howard et al. (2014) Young adults who smoke cigarettes and marijuana: analysis of thoughts and behaviors. Addict Behav 39:77-84
Ramo, Danielle E; Delucchi, Kevin L; Hall, Sharon M et al. (2013) Marijuana and tobacco co-use in young adults: patterns and thoughts about use. J Stud Alcohol Drugs 74:301-10
Hall, Sharon M; Humfleet, Gary L; Munoz, Ricardo F et al. (2011) Using extended cognitive behavioral treatment and medication to treat dependent smokers. Am J Public Health 101:2349-56
Hendricks, Peter S; Wood, Sabrina B; Baker, Majel R et al. (2011) The Smoking Abstinence Questionnaire: measurement of smokers' abstinence-related expectancies. Addiction 106:716-28

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