The proposed K05 RSA will focus on the following three areas to improve the candidate's career development: 1) learning more about genetics and brain circuitry related to the development of antisocial behavior (AB) and drug use;2) further developing the use of the Family Check Up intervention for use with different age groups and at-risk populations;and 3) learning more about the interface among research-based intervention programs, community needs, and social policy. Skills acquired from the career development plan should have both short- and long-term applications to the candidate's research. The candidate proposes to conduct four funded programs of research. Program I (NIMH R01-50907) seeks to advance our understanding of the precursors of early- and late-starting pathways of antisocial behavior (AB) by following a cohort of low-income, male youth from ages 1.5 to 18. Program II, the Early Steps - Multisite (ES-M) Project (NIDA R01 016110), is a prevention study targeting family and extra-familial influences in early and middle childhood to reduce risk for early-onset AB, drug use, and HIV risk. Program III, the Parental Involvement and Extra-Familial Contexts Project (NIDA R01 023245), uses families from the ES-M sample to examine the contributions of neighborhood, school, and after-school care contexts in relation to drug use risk during middle childhood, and how parental involvement in these extra-familial settings may attenuate effects of extra-familial risk factors on drug use risk. Program IV represents two studies that have emerged as extensions from the Early Growth and Development Study (EGDS, NICHD R01 12709). Both studies (NICHD R01 042608 &NIDA R01 020585) use an adoption design to examine mechanisms by which genetic factors, prenatal drug exposure, and parent-child relationships influence developmental pathways leading to problem behavior and social competence in early childhood. The purpose of the K05 RSA is to permit the candidate to conduct these four programs of research and broaden his understanding basic and applied issues related to the prevention of drug use risk from early childhood through adolescence.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Scientist Award (K05)
Project #
5K05DA025630-04
Application #
8316389
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Sims, Belinda E
Project Start
2009-09-01
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
4
Fiscal Year
2012
Total Cost
$127,429
Indirect Cost
$9,439
Name
University of Pittsburgh
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Galán, Chardée A; Choe, Daniel Ewon; Forbes, Erika E et al. (2017) Interactions between empathy and resting heart rate in early adolescence predict violent behavior in late adolescence and early adulthood. J Child Psychol Psychiatry 58:1370-1380
Gard, Arianna M; Waller, Rebecca; Shaw, Daniel S et al. (2017) The long reach of early adversity: Parenting, stress, and neural pathways to antisocial behavior in adulthood. Biol Psychiatry Cogn Neurosci Neuroimaging 2:582-590
Shaw, Daniel S; Gilliam, Mary (2017) EARLY CHILDHOOD PREDICTORS OF LOW-INCOME BOYS' PATHWAYS TO ANTISOCIAL BEHAVIOR IN CHILDHOOD, ADOLESCENCE, AND EARLY ADULTHOOD. Infant Ment Health J 38:68-82
Murray, Laura; Shaw, Daniel S; Forbes, Erika E et al. (2017) Reward-Related Neural Correlates of Antisocial Behavior and Callous-Unemotional Traits in Young Men. Biol Psychiatry Cogn Neurosci Neuroimaging 2:346-354
Sitnick, Stephanie L; Shaw, Daniel S; Weaver, Chelsea M et al. (2017) Early Childhood Predictors of Severe Youth Violence in Low-Income Male Adolescents. Child Dev 88:27-40
Waller, Rebecca; Shaw, Daniel S; Hyde, Luke W (2017) Observed fearlessness and positive parenting interact to predict childhood callous-unemotional behaviors among low-income boys. J Child Psychol Psychiatry 58:282-291
Mattson, Whitney I; Hyde, Luke W; Shaw, Daniel S et al. (2016) Clinical neuroprediction: Amygdala reactivity predicts depressive symptoms 2 years later. Soc Cogn Affect Neurosci 11:892-8
Hyde, Luke W; Shaw, Daniel S; Murray, Laura et al. (2016) Dissecting the role of amygdala reactivity in antisocial behavior in a sample of young, low-income, urban men. Clin Psychol Sci 4:527-544
Shaw, Daniel S; Sitnick, Stephanie L; Reuben, Julia et al. (2016) Transactional effects among maternal depression, neighborhood deprivation, and child conduct problems from early childhood through adolescence: A tale of two low-income samples. Dev Psychopathol 28:819-36
Shaw, Daniel S; Sitnick, Stephanie L; Brennan, Lauretta M et al. (2016) The long-term effectiveness of the Family Check-Up on school-age conduct problems: Moderation by neighborhood deprivation. Dev Psychopathol 28:1471-1486

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