The purpose of this Senior Scientist Research and Mentorship Award (K05) application is to allow me (Richard W. Foltin, Ph.D.) protected time so that I may continue to mentor junior faculty. In this way I will share with the junior faculty much of what I learned from my mentors and in turn have my research benefit from what I learn from the junior faculty. Specifically, I will share my experience in conducting well-controlled, laboratory- based studies in areas that are difficult to model (relapse, putative medication effects on drug self- administration, estimating reinforcing values of behavior) with junior colleagues who are hoping to bring similar powerful methodologies to bear on their areas of expertise. Goal 1. Research:
Aim 1. Maintain active research programs using laboratory models of drug abuse in non-human primates and drug-experienced human volunteers. My active support has always played a role in providing both research opportunities and salary support for junior faculty. I have 2 active R01s and 2 pending R01 submissions that will be used to support my research and provide training opportunities.
Aim 2. Expand my research interests by incorporating the expertise of junior faculty I am mentoring in neuropsychology, magnetic resonance imaging, eating disorders and geriatric psychiatry. Goal 2. Training:
Aim 1. Continue to be a valuable resource to the more senior faculty in our research group whom I have mentored since they completed their postdoctoral fellowships.
Aim 2. Help the individuals whom I mentored on their K awards who are in their 4th and 5th years and now transitioning to independent status.
Aim 3. Provide guidance to the individuals whom I mentor that are in the first several years of their K awards.
Aim 4. Keep a discernible profile in departmental affairs so that I can be an advocate for drug abuse research and the needs of junior faculty. I have sufficient mentoring responsibilities to account for my mentoring effort over the next 5 years. Generally the junior faculty I mentor will first conduct projects that will be funded as part of one of my R01s, and then apply for divisional funds for pilot studies where possible prior to submitting a K application. This model has worked well in the past and will be used to develop new K awards for junior faculty.

Public Health Relevance

The purpose of this Senior Scientist Research and Mentorship Award (K05) application is to allow me (Richard W. Foltin, Ph.D.) protected time so that I may continue to mentor junior faculty. I will share my experience in conducting well-controlled, laboratory-based studies in areas that are difficult to model (relapse, putative medication effects on drug self-administration, estimating reinforcing values of behavior) with junior colleagues who are hoping to bring similar powerful methodologies to bear on their areas of expertise.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Scientist Award (K05)
Project #
5K05DA031749-02
Application #
8286888
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Kautz, Mary A
Project Start
2011-07-01
Project End
2016-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
2
Fiscal Year
2012
Total Cost
$128,207
Indirect Cost
$9,497
Name
Columbia University (N.Y.)
Department
Psychiatry
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Evans, Suzette M; Foltin, Richard W; Hicks, Martin J et al. (2016) Efficacy of an adenovirus-based anti-cocaine vaccine to reduce cocaine self-administration and reacqusition using a choice procedure in rhesus macaques. Pharmacol Biochem Behav 150-151:76-86
Carpenter, Kenneth M; Amrhein, Paul C; Bold, Krysten W et al. (2016) Derived relations moderate the association between changes in the strength of commitment language and cocaine treatment response. Exp Clin Psychopharmacol 24:77-89
Foltin, Richard W; Haney, Margaret; Bedi, Gillinder et al. (2016) Modafinil decreases cocaine choice in human cocaine smokers only when the response requirement and the alternative reinforcer magnitude are large. Pharmacol Biochem Behav 150-151:8-13
Askalsky, Paula; Kalapatapu, Raj K; Foltin, Richard W et al. (2015) Butyrylcholinesterase levels and subjective effects of smoked cocaine in healthy cocaine users. Am J Drug Alcohol Abuse 41:161-5
Hicks, Martin J; Kaminsky, Stephen M; De, Bishnu P et al. (2014) Fate of systemically administered cocaine in nonhuman primates treated with the dAd5GNE anticocaine vaccine. Hum Gene Ther Clin Dev 25:40-9
Wu, Melody V; Shamy, Jul Lea; Bedi, Gillinder et al. (2014) Impact of social status and antidepressant treatment on neurogenesis in the baboon hippocampus. Neuropsychopharmacology 39:1861-71
Dakwar, Elias; Levin, Frances; Foltin, Richard W et al. (2014) The effects of subanesthetic ketamine infusions on motivation to quit and cue-induced craving in cocaine-dependent research volunteers. Biol Psychiatry 76:40-6
Haney, Margaret; Bedi, Gillinder; Cooper, Ziva D et al. (2013) Predictors of marijuana relapse in the human laboratory: robust impact of tobacco cigarette smoking status. Biol Psychiatry 73:242-8
Haney, Margaret; Cooper, Ziva D; Bedi, Gillinder et al. (2013) Nabilone decreases marijuana withdrawal and a laboratory measure of marijuana relapse. Neuropsychopharmacology 38:1557-65
Cooper, Ziva D; Foltin, Richard W; Evans, Suzette M (2013) Effects of menstrual cycle phase on cocaine self-administration in rhesus macaques. Horm Behav 63:105-13

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