Abstract

The Subcommittee scored in full time and amount this competing renewal Senior Research Scientist Development Award (K05) application to continue the Candidate's long-standing research program regarding the molecular mechanism of opioid drugs and to determine the molecular and gene structure of opioid receptors in immune cells and periaqueductal gray (PAG) with special attention to understanding tissue specific regulation of opioid receptor gene expression and the molecular basis of opioid tolerance/dependence.Scoring was recommended because the Candidate has an excellent record over the past 20 years in helping to characterize the opioid receptor system. This commitment to opiate research over the years has provided enormous impetus to the field. He has trained numerous investigators who have gone on to establish excellent laboratories of their own. This work is state of the art and far-sighted; this award will provide him with the means to continue his endeavor. No human subjects are involved. Vertebrate animals (rats, mice, rabbits) will be used in accordance with accepted humane standards and their care was judged to be adequate.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Scientist Award (K05)
Project #
5K05DA070554-26
Application #
2749209
Study Section
Drug Abuse Biomedical Research Review Committee (DABR)
Program Officer
Colvis, Christine
Project Start
1989-08-01
Project End
1999-07-31
Budget Start
1998-09-15
Budget End
1999-07-31
Support Year
26
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Pharmacology
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Wagley, Yadav; Hwang, Cheol Kyu; Lin, Hong-Yiou et al. (2013) Inhibition of c-Jun NH2-terminal kinase stimulates mu opioid receptor expression via p38 MAPK-mediated nuclear NF-?B activation in neuronal and non-neuronal cells. Biochim Biophys Acta 1833:1476-88
Song, Kyu Young; Choi, Hack Sun; Law, Ping-Yee et al. (2012) Post-transcriptional regulation of mu-opioid receptor: role of the RNA-binding proteins heterogeneous nuclear ribonucleoprotein H1 and F. Cell Mol Life Sci 69:599-610
Hwang, Cheol Kyu; Wagley, Yadav; Law, Ping-Yee et al. (2012) MicroRNAs in opioid pharmacology. J Neuroimmune Pharmacol 7:808-19
Zheng, Hui; Chu, Ji; Zhang, Yuhan et al. (2011) Modulating micro-opioid receptor phosphorylation switches agonist-dependent signaling as reflected in PKCepsilon activation and dendritic spine stability. J Biol Chem 286:12724-33
Kim, Do Kyung; Hwang, Cheol Kyu; Wagley, Yadav et al. (2011) p38 mitogen-activated protein kinase and PI3-kinase are involved in up-regulation of mu opioid receptor transcription induced by cycloheximide. J Neurochem 116:1077-87
Wei, Li-Na; Loh, Horace H (2011) Transcriptional and epigenetic regulation of opioid receptor genes: present and future. Annu Rev Pharmacol Toxicol 51:75-97
Chu, Ji; Zheng, Hui; Zhang, Yuhan et al. (2010) Agonist-dependent mu-opioid receptor signaling can lead to heterologous desensitization. Cell Signal 22:684-96
Song, Kyu Young; Kim, Chun Sung; Hwang, Cheol Kyu et al. (2010) uAUG-mediated translational initiations are responsible for human mu opioid receptor gene expression. J Cell Mol Med 14:1113-24
Tao, Pao-Luh; Law, Ping-Yee; Loh, Horace H (2010) Search for the ""ideal analgesic"" in pain treatment by engineering the mu-opioid receptor. IUBMB Life 62:103-11
Zheng, Hui; Zeng, Yan; Chu, Ji et al. (2010) Modulations of NeuroD activity contribute to the differential effects of morphine and fentanyl on dendritic spine stability. J Neurosci 30:8102-10

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