A.
SPECIFIC AIMS The original aims have not been modified. Research continued with focus on three major inter-relatedtopics, namely stroke prevention by risk detection via physiological monitoring, the implementation of suchmonitoring worldwide via BIOCOS (the study of effects of the BlOsphere and the COSmos on biota), andthereby the mapping of about-weekly, half-weekly (circaseptan and circasemiseptan) and other componentsin spectra covering over 10 orders of magnitude. The 7-day/24-hour monitoring of blood pressure and heartrate was emphasized for the identification of disease risk syndromes involving alterations not only in meanvalues but in the variability of blood pressure and heart rate, including their circadian and circaseptanpatterns. Monitoring continued at all participating centers. In particular, citizens of Urausu and Tosa, Japan,where the awardee was invited to lecture this year, are being screened with additional focus on severalindices of quality of life assessed by questionnaires [59-62]t and where outcomes are becoming available.The study of non-photic solar effects on physiology and pathology has been pursued. New findingsinclude the demonstration of an about 1.3-year component detected in new and updated records of bloodpressure and heart rate spanning up to 40 years, matching the 1.3-year cycle in solar wind speed reportedby John D. Richardson [40, 41, 54, 91, 138, 158, 164, 173]. An about 1.3-year component has notably beenobserved in the incidence of sudden cardiac death (ICD10, 146.1) in Minnesota and in several othergeographic locations, in the absence of a 1-year synchronized component. The mapping of new non-photicas well as of known photic cycles has continued [87, 127, 133, 153]. This work led to the birth of the newfield of chronomics and the start of an atlas of chronomes, the major topic to be pursued in the next fewyears.About-weekly and half-weekly components are now routinely assessed from the 7-day/24-hour profiles ofblood pressure and heart rate measured around the clock at 30-min intervals. Summaries of data bases intNumbers in square brackets refer to titles listed under Publications by awardee.the city of Urausu (Hokkaido, Japan) revealed a more pronounced circaseptan variation among depressivesubjects [59].In summary, three major themes in the activities of the awardee were pursued, namely1. the development of treatment modalities of new disease risk syndromes;2. the assessment of non-photic as well as photic effects on life forms, including influences from helio- andgeomagnetics on human physiology and pathology; the mapping of such low frequency components wasstarted, underlying the new field of chronomics; and3. the mapping of chronomes in selected species, with focus on the relative importance of the biological dayvs. the biological week and of the transyear vs. the calendar year.
| Halberg, F; Düll-Pfaff, N; Gumarova, L et al. (2013) 27-day cycles in human mortality: Traute and Bernhard Düll. Hist Geo Space Sci 4: |
| Gumarova, L; Cornelissen, G; Hillman, D et al. (2013) Geographically selective assortment of cycles in pandemics: meta-analysis of data collected by Chizhevsky. Epidemiol Infect 141:2173-84 |
| Halberg, Franz; Mult, Hc; Cornélissen, Germaine et al. (2012) Chronobiologically Interpreted Ambulatory Blood Pressure Monitoring in Health and Disease. Glob Adv Health Med 1:66-123 |
| Halberg, Franz; Cornelissen, Germaine; Sothern, Robert B et al. (2012) Decadal Cycles in the Human Cardiovascular System. World Heart J 4:263-287 |
| Pan, Weihong; Hsuchou, Hung; Cornelissen-Guillaume, Germaine G et al. (2012) Endothelial leptin receptor mutation provides partial resistance to diet-induced obesity. J Appl Physiol (1985) 112:1410-8 |
| Cornelissen, Germaine; Burioka, Naoto; Halberg, Franz (2012) Other-than-annual variations in morning determinations of uric acid. Clin Chem Lab Med 50:765-70 |
| Pan, Weihong; Wu, Xiaojun; Kastin, Abba J et al. (2011) Potential protective role of IL15Rýý during inflammation. J Mol Neurosci 43:412-23 |
| Halberg, Franz; Cornélissen, Germaine; Singh, R B (2011) Timing Nutriceuticals? Open Nutraceuticals J 3:100-111 |
| Halberg, F; Cornélissen, G; Bernhardt, K-H et al. (2010) Egeson's (George's) transtridecadal weather cycling and sunspots. Hist Geo Space Sci 1:49-61 |
| Halberg, F; Cornélissen, G; Katinas, G S et al. (2010) COSMIC INHERITANCE RULES: IMPLICATIONS FOR HEALTH CARE AND SCIENCE. Scr Med (Brno) 83:5-15 |
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