The present Academic Leadership Award (K07) application is to request support for Sanjay Asthana, MD to integrate the.remarkable resources of the University of Wisconsin (UW)-Madison, and develop a comprehensive, translational, interdisciplinary, and campus-wide research program in Alzheimer's disease (AD). The UW has a long and distinguished history of conducting cutting edge research in neuroscience; however, the university does not currently sponsor a dedicated program in AD research on its campus. Establishing a preeminent research program in AD is one of the top strategic priorities for UW. To that end, recent recruitment of Dr. Asthana from the University of Washington into a leadership position in gerontology, and commitment of substantial institutional resources has facilitated establishment of a preeminent AD research program at UW. It is anticipated that this program will form the basis for a NIA- funded Alzheimer's Disease Research Center (ADRC) at UW. The major objectives of the proposed AD research Program include the following: 1. To bring together extensive resources and infrastructure of UW toward developing a campus-wide, interdisciplinary, and translational research program in AD. 2. To develop various """"""""research cores"""""""" necessary to establish a NIH-funded Alzheimer's Disease Research Center (ADRC) at UW. 3. To develop a comprehensive training program related to the neurobiology, diagnosis, and treatment of AD. 4. To enhance the interest and attract some of the current UW neuroscience faculty members into AD research.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Academic/Teacher Award (ATA) (K07)
Project #
5K07AG021582-04
Application #
7558986
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Silverberg, Nina B
Project Start
2006-04-15
Project End
2011-01-31
Budget Start
2009-04-01
Budget End
2010-01-31
Support Year
4
Fiscal Year
2009
Total Cost
$108,000
Indirect Cost
Name
University of Wisconsin Madison
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Carlsson, Cynthia M; Xu, Guofan; Wen, Zhifei et al. (2012) Effects of atorvastatin on cerebral blood flow in middle-aged adults at risk for Alzheimer's disease: a pilot study. Curr Alzheimer Res 9:990-7
Wharton, Whitney; Baker, Laura D; Gleason, Carey E et al. (2011) Short-term hormone therapy with transdermal estradiol improves cognition for postmenopausal women with Alzheimer's disease: results of a randomized controlled trial. J Alzheimers Dis 26:495-505
Wharton, Whitney; Dowling, Maritza; Khosropour, Christine M et al. (2009) Cognitive benefits of hormone therapy: cardiovascular factors and healthy-user bias. Maturitas 64:182-7
Watson, G Stennis; Baker, Laura D; Cholerton, Brenna A et al. (2009) Effects of insulin and octreotide on memory and growth hormone in Alzheimer's disease. J Alzheimers Dis 18:595-602
Hermann, Bruce; Seidenberg, Michael; Sager, Mark et al. (2008) Growing old with epilepsy: the neglected issue of cognitive and brain health in aging and elder persons with chronic epilepsy. Epilepsia 49:731-40
La Rue, Asenath; Hermann, Bruce; Jones, Jana E et al. (2008) Effect of parental family history of Alzheimer's disease on serial position profiles. Alzheimers Dement 4:285-90