Epidemiology is an inherently multidisciplinary, translational field of study that examines the distribution and determinants of disease in the population. Although its basic building blocks of prevalence, incidence, and risk factors are widely acknowledged, its role in clinical and translational research is less well appreciated and utilized. Epidemiology can contribute to guiding clinical trials design, to validating diagnostic criteria and biomarkers, to identifying - at the population level - signals of potential disease mechanisms to be investigated at the clinical and laboratory levels. The Candidate is a seasoned psychiatrist and neuroepidemiologist. This K07 Leadership Award in Aging will allow her to develop a new program at the University of Pittsburgh in the epidemiology of brain and behavior in aging. Specifically, 3 groups of activities are proposed: (1) A multi-level curriculum in Aging Brain-Behavior Epidemiology, with several classes and seminars targeting clinical residents and fellows, psychology interns, postdoctoral scholars, and faculty in neurology, psychiatry, geriatric medicine, psychology, and epidemiology, building on and expanding currently available educational offerings. (2) A multidisciplinary Research Forum on Cancer and Neurodegeneration, based on intriguing epidemiologic evidence of an inverse relationship between neurodegeneration and certain cancers. This Forum will bring together researchers from clinical, basic, and translational neuroscience, neuroepidemiologists, oncologists, cancer epidemiologists, geneticists, immunologists, and related disciplines, to review and discuss emerging science, generate innovative hypotheses leading to pilot studies, and collaborative research. (3) A range of Research Practice offering mentored research opportunities to early stage investigators, including (i) a novel study of cognitive impairment in a cohort of middle-aged women who have been well-characterized for alcohol and cannabis use and followed for 22 years;(ii) secondary analyses of data from the Candidate's four large epidemiologic studies of cognitive impairment and dementia;(iii) pilot studies derived from the forum on cancer and neurodegeneration. This program will also organize conferences to broadly disseminate results of research as well as curricular efforts. Thus, it will introduce educational enhancements and catalyze innovative multidisciplinary translational research with a population perspective. It will not only generate new science but result in the development of a multidisciplinary cadre of investigators who will be equipped with a sound grasp of critical epidemiological principles and methods to inform their research into brain disorders of aging.

Public Health Relevance

This K07 Leadership Award in Aging will allow the Candidate, Dr. Mary Ganguli, to develop a research education and training program in the Epidemiology of Aging Brain and Behavior at the University of Pittsburgh. This program will offer classes and seminars to trainees and faculty across disciplines that study brain disorders (psychiatry, neurology, and neuroscience), provide mentored research opportunities in epidemiology, and also develop a multidisciplinary forum to discuss and study the intriguing relationships between brain degeneration and certain cancers.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Academic/Teacher Award (ATA) (K07)
Project #
1K07AG044395-01
Application #
8485092
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Wagster, Molly V
Project Start
2013-09-30
Project End
2018-06-30
Budget Start
2013-09-30
Budget End
2014-06-30
Support Year
1
Fiscal Year
2013
Total Cost
$126,206
Indirect Cost
$9,349
Name
University of Pittsburgh
Department
Psychiatry
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Graziane, Julie A; Beer, Joanne C; Snitz, Beth E et al. (2016) Dual Trajectories of Depression and Cognition: A Longitudinal Population-Based Study. Am J Geriatr Psychiatry 24:364-73
Ganguli, Mary (2016) The times they are a-changin': cohort effects in aging, cognition, and dementia. Int Psychogeriatr :1-3
McDade, Eric; Sun, Zhaowen; Lee, Ching-Wen et al. (2016) The association between pulse pressure change and cognition in late life: Age and where you start matters. Alzheimers Dement (Amst) 4:56-66
Nimgaonkar, Vishwajit L; Yolken, Robert H; Wang, Tianxiu et al. (2015) Temporal Cognitive Decline Associated With Exposure to Infectious Agents in a Population-based, Aging Cohort. Alzheimer Dis Assoc Disord :
Ganguli, Mary (2015) Cancer and Dementia: It's Complicated. Alzheimer Dis Assoc Disord 29:177-82
Ganguli, Mary; Lee, Ching-Wen; Snitz, Beth E et al. (2015) Rates and risk factors for progression to incident dementia vary by age in a population cohort. Neurology 84:72-80
Snitz, Beth E; Small, Brent J; Wang, Tianxiu et al. (2015) Do Subjective Memory Complaints Lead or Follow Objective Cognitive Change? A Five-Year Population Study of Temporal Influence. J Int Neuropsychol Soc 21:732-42
Ganguli, Mary; Lotze, Michael T (2015) Parkinson Disease and Malignant Disease: Minding Cancer's Own Business. JAMA Oncol 1:641-2
Ganguli, Mary; Lee, Ching-Wen; Hughes, Tiffany et al. (2015) Who wants a free brain scan? Assessing and correcting for recruitment biases in a population-based sMRI pilot study. Brain Imaging Behav 9:204-12
Andreescu, Carmen; Teverovsky, Esther; Fu, Bo et al. (2014) Old worries and new anxieties: behavioral symptoms and mild cognitive impairment in a population study. Am J Geriatr Psychiatry 22:274-84

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