The Cancer Prevention, Control, and Population Sciences Career Development Award is requested to support the career development of Dr. Julie Britton, who is a classically trained cancer epidemiologist. The primary aim of the K07 grant is to position Dr. Britton as an independent research scientist specializing in relationships between energy balance and cancer risk.
The research aims -relating energy balance to breast cancer risk- will be examined in a large case-control study of breast cancer among African American women in New York City. ? ? Traditional chronic disease epidemiology focuses on single risk factor-disease associations at the individual level with little consideration of their biological or social context, an approach that is often referred to as """"""""black box"""""""" epidemiology. Dr. Britton's career goal is to advance beyond the """"""""black box"""""""" that currently obscures relationships between energy balance and cancer risk. Her training program will enable her to acquire in-depth knowledge of the three energy balance components (body size characteristics, diet, and physical activity), better understanding of the physiological basis of energy balance, and proficiency in the essential statistical techniques necessary to incorporate all three risk components into an analytic model. In addition, training will address conducting and translating research in minority populations. The training program includes an internship, graduate coursework, and attendance at carefully chosen symposia and national meetings. Dr. Britton's proposal is sponsored by Drs. Mary Wolff and Christine Ambrosone (molecular epidemiology) and Dr. Larry Kushi (nutritional epidemiology). Additional advisors in two highly specialized areas of energy balance will be Drs. Steven Heymsfield (characteristics of body size) and Leslie Bernstein (physical activity and reproductive cancers). ? ? Body size characteristics, dietary intake, and physical activity have been associated with breast cancer risk among Caucasian women. These energy balance components are also strongly suspected to be risk factors for the disease in African American women. However, despite steadily increasing rates of incidence and mortality from breast cancer, research is sparse among African Americans. Results of the proposed research project will be of enormous public health relevance since they may advance our knowledge of modifiable breast cancer risk factors among a high-risk group of women, thereby providing information that is essential for primary prevention.
|Sheffield, Perry E; Uijttewaal, Simone A M; Stewart, James et al. (2017) Climate Change and Schools: Environmental Hazards and Resiliency. Int J Environ Res Public Health 14:|
|Wolff, Mary S; Teitelbaum, Susan L; Pinney, Susan M et al. (2010) Investigation of relationships between urinary biomarkers of phytoestrogens, phthalates, and phenols and pubertal stages in girls. Environ Health Perspect 118:1039-46|
|Britton, Julie A; Khan, Aneire E; Rohrmann, Sabine et al. (2008) Anthropometric characteristics and non-Hodgkin's lymphoma and multiple myeloma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Haematologica 93:1666-77|
|Dettenborn, Lucia; James, Gary D; Britton, Julie A et al. (2008) Higher levels of central adiposity in healthy premenopausal women with family histories of premenopausal breast cancer. Am J Hum Biol 20:355-8|
|Teitelbaum, S L; Britton, J A; Calafat, A M et al. (2008) Temporal variability in urinary concentrations of phthalate metabolites, phytoestrogens and phenols among minority children in the United States. Environ Res 106:257-69|
|Wolff, Mary S; Teitelbaum, Susan L; Windham, Gayle et al. (2007) Pilot study of urinary biomarkers of phytoestrogens, phthalates, and phenols in girls. Environ Health Perspect 115:116-21|
|Wolff, Mary S; Anderson, Henry A; Britton, Julie A et al. (2007) Pharmacokinetic variability and modern epidemiology--the example of dichlorodiphenyltrichloroethane, body mass index, and birth cohort. Cancer Epidemiol Biomarkers Prev 16:1925-30|
|Wolff, Mary S; Britton, Julie A; Teitelbaum, Susan L et al. (2005) Improving organochlorine biomarker models for cancer research. Cancer Epidemiol Biomarkers Prev 14:2224-36|