Dr. Wendy Setiawan received her Ph.D. in epidemiology from UCLA in 2002. She completed a year of postdoctoral training at Harvard and is currently at the Department of Preventive Medicine at USC where she is part of the highly interactive population/cancer genetics group headed by Dr. Brian E. Henderson. The goal of this career development award is to provide Dr. Setiawan with the knowledge and necessary skills to become an independent cancer researcher. A combination of research project, structured courses, seminars, workshops, and mentoring has been designed to accomplish this goal. Two highly qualified and experienced mentors with relevant expertise, Dr. Henderson (cancer epidemiology) and Dr. Duncan Thomas (biostatistics and genetics), will supervise her training. The scientific culture and collaborative research atmosphere in the department provide an ideal environment for the candidate's academic career development. The objective of Dr. Setiawan's research project is to identify environmental and genetic determinants of circulating endogenous sex-steroid hormone levels, because there are substantial inter-individual variations in circulating hormone levels and postmenopausal women with elevated estrogens and androgens are at an increased risk of breast cancer. A cross-sectional study of healthy postmenopausal women from the Multiethnic Cohort Study (MEC) will be conducted to 1) determine whether known/potential breast cancer risk factors are associated with plasma hormone levels, 2) characterize genetic variation of estrogen biosynthesis genes (CYP11A, CYP17, CYP19, HSD3B1, HSD3B2, HSD17B1, HSD17B2, and SHBG) using a two-pronged approach (putative functional variants and inferred haplotypes) and evaluate these in relation to hormone levels; 3) develop and implement a Bayesian hierarchical statistical model that allows for an efficient and pathway-driven examination of multiple gene-gene and a priori gene-environment interactions in influencing hormone levels. The unique feature of the proposed study is that it integrates a large multiethnic population-based study, cutting edge genomic resources, and novel statistical approaches to identify genetic and environmental factors responsible for inter-individual variations in endogenous hormone levels. Identification of these factors is important to understand the mechanisms by which they could influence breast cancer risk and ultimately to identify high-risk women for prevention strategies.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Academic/Teacher Award (ATA) (K07)
Project #
1K07CA116543-01A2
Application #
7194556
Study Section
Subcommittee G - Education (NCI)
Program Officer
Gorelic, Lester S
Project Start
2006-09-18
Project End
2011-08-31
Budget Start
2006-09-18
Budget End
2007-08-31
Support Year
1
Fiscal Year
2006
Total Cost
$121,552
Indirect Cost
Name
University of Southern California
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Setiawan, Veronica Wendy; Haessler, Jeffrey; Schumacher, Fredrick et al. (2012) HNF1B and endometrial cancer risk: results from the PAGE study. PLoS One 7:e30390
Setiawan, Veronica Wendy; Matsuno, Rayna K; Lurie, Galina et al. (2012) Use of nonsteroidal anti-inflammatory drugs and risk of ovarian and endometrial cancer: the Multiethnic Cohort. Cancer Epidemiol Biomarkers Prev 21:1441-9
Park, Sungshim Lani; Le Marchand, Loïc; Wilkens, Lynne R et al. (2012) Risk factors for malignant melanoma in white and non-white/non-African American populations: the multiethnic cohort. Cancer Prev Res (Phila) 5:423-34
Lee, Eunjung; Hsu, Chris; Haiman, Christopher A et al. (2010) Genetic variation in the progesterone receptor gene and risk of endometrial cancer: a haplotype-based approach. Carcinogenesis 31:1392-9
Park, Sungshim Lani; Goodman, Marc T; Zhang, Zuo-Feng et al. (2010) Body size, adult BMI gain and endometrial cancer risk: the multiethnic cohort. Int J Cancer 126:490-9
Setiawan, Veronica Wendy; Kolonel, Laurence N; Henderson, Brian E (2009) Menstrual and reproductive factors and risk of renal cell cancer in the Multiethnic Cohort. Cancer Epidemiol Biomarkers Prev 18:337-40
Setiawan, Veronica Wendy; Monroe, Kristine R; Wilkens, Lynne R et al. (2009) Breast cancer risk factors defined by estrogen and progesterone receptor status: the multiethnic cohort study. Am J Epidemiol 169:1251-9
Setiawan, Veronica Wendy; Doherty, Jennifer A; Shu, Xiao-Ou et al. (2009) Two estrogen-related variants in CYP19A1 and endometrial cancer risk: a pooled analysis in the Epidemiology of Endometrial Cancer Consortium. Cancer Epidemiol Biomarkers Prev 18:242-7
Setiawan, Veronica Wendy; Monroe, Kristine R; Goodman, Marc T et al. (2008) Alcohol consumption and endometrial cancer risk: the multiethnic cohort. Int J Cancer 122:634-8
Setiawan, Veronica Wendy; Pike, Malcolm C; Kolonel, Laurence N et al. (2007) Racial/ethnic differences in endometrial cancer risk: the multiethnic cohort study. Am J Epidemiol 165:262-70

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