My goal for this career development award is to become an independent researcher specializing in the development and application of statistical methods for behavioral lifestyle interventions. I am a biostatistician with significant experience analyzing data from randomized clinical trials and developing methods for handling missing data. This K07 award will build on this past experience by: (1) providing training in diet and physical activity interventions, focusing on assessment, adherence, and the determinants of lifestyle behaviors, and (2) providing mentored guidance to develop statistical methods specifically designed to analyze real-time diet and activity data that is gathered in clinical trials of behavioral interventions. To achieve these goals, I have developed a comprehensive educational plan, including expert mentors consisting of a behavioral interventionist, a biostatistician who specializes in behavioral interventions, a kinesiologist whose research expertise is in physical activity assessment, a nutritional epidemiologist, and a statistician who is an expert in the analysis of accelerometer output. The research I have proposed both reinforces my training and provides original, innovative statistical methodology to answer important questions regarding behavioral interventions. The research plan focuses on the following specific aims: 1) Develop statistical models to investigate the effects of physical activity on diet at the real-time level. 2) Identify the factors which are predictive of long-term behavior change. 3) Extend the statistical models in aims 1 and 2 by relaxing assumptions regarding missing data. The research and training in this career development award will prepare me to be a principal investigator on research projects and grants that develop statistical methodology to investigate mechanisms of behavior change and improve the assessment of diet and activity behaviors.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Academic/Teacher Award (ATA) (K07)
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Study Section
Subcommittee G - Education (NCI)
Program Officer
Perkins, Susan N
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Northwestern University at Chicago
Public Health & Prev Medicine
Schools of Medicine
United States
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Siddique, Juned; de Chavez, Peter J; Howe, George et al. (2018) Limitations in Using Multiple Imputation to Harmonize Individual Participant Data for Meta-Analysis. Prev Sci 19:95-108
Spring, Bonnie; Pellegrini, Christine; McFadden, H G et al. (2018) Multicomponent mHealth Intervention for Large, Sustained Change in Multiple Diet and Activity Risk Behaviors: The Make Better Choices 2 Randomized Controlled Trial. J Med Internet Res 20:e10528
Brincks, Ahnalee; Montag, Samantha; Howe, George W et al. (2018) Addressing Methodologic Challenges and Minimizing Threats to Validity in Synthesizing Findings from Individual-Level Data Across Longitudinal Randomized Trials. Prev Sci 19:60-73
Siddique, Juned; de Chavez, Peter John; Craft, Lynette L et al. (2017) The Effect of Changes in Physical Activity on Sedentary Behavior: Results From a Randomized Lifestyle Intervention Trial. Am J Health Promot 31:287-295
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Murthy, Venkatesh L; Abbasi, Siddique A; Siddique, Juned et al. (2016) Transitions in Metabolic Risk and Long-Term Cardiovascular Health: Coronary Artery Risk Development in Young Adults (CARDIA) Study. J Am Heart Assoc 5:
Schneider, Kristin L; Coons, Michael J; McFadden, H Gene et al. (2016) Mechanisms of Change in Diet and Activity in the Make Better Choices 1 Trial. Health Psychol :
Womack, Veronica Y; De Chavez, Peter John; Albrecht, Sandra S et al. (2016) A Longitudinal Relationship Between Depressive Symptoms and Development of Metabolic Syndrome: The Coronary Artery Risk Development in Young Adults Study. Psychosom Med 78:867-73
Barreira, Tiago V; Hamilton, Marc T; Craft, Lynette L et al. (2016) Intra-individual and inter-individual variability in daily sitting time and MVPA. J Sci Med Sport 19:476-81

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