This career development application proposes a mentored training and research experience to develop John Salsman, Ph.D., as an independent investigator in the development of innovative positive psychological outcome measures for cancer prevention and control. Patient-reported outcomes (PROs) capture the patient's unique perspective on the impact of chronic diseases such as cancer and assess subjective experience in ways distinct from physiological outcomes. The Patient-Reported Outcomes Measurement Information System (PROMIS) is an NIH Roadmap initiative designed to improve and standardize PROs for patients with a wide range of chronic diseases and demographic characteristics using state-of-the-art psychometric methods. It is an ambitious and comprehensive PRO measurement system that applies item response theory (IRT) modeling to health status assessment. PROMIS has developed and calibrated item banks assessing emotional distress, sleep-wake function, physical function, pain, fatigue, and social health. There remains a gap in the PROMIS domain framework, with no current banks assessing positive psychological functioning (PPF). As more people survive and even thrive with cancer, understanding positive adjustment and growth in cancer is an important complement to understanding impairment, disability and psychosocial morbidity in cancer prevention and control research. Dr. Salsman proposes (1) to develop new item banks for positive psychological functioning (PPF) to augment and expand the existing PROMIS item banks, (2) to explore the utility of the PPF banks across the cancer care continuum using multiple assessments with a heterogeneous group of cancer patients and survivors, and (3) to adapt and pilot test an intervention to promote well-being among young adult cancer patients and survivors to determine feasibility and acceptability. Results will lead to further refinement of innovative measures of PPF and guide development of future interventions to minimize the adverse impact of cancer and enhance adaptive functioning. The proposed research is supported by a training plan that involves interactions with multidisciplinary colleagues and formal coursework in clinical trials, qualitative methodologies, biostatistics, psychometrics, and positive psychology.

Public Health Relevance

The purpose of the proposed research is to develop innovative measures of positive functioning for use in patient care research using modern measure development strategies. We will examine the relationship of these positive variables to important outcomes such as physical symptoms, quality of life, and health behaviors in a group of cancer patients and survivors. These results will help us understand the role of positive psychological functioning in the cancer experience and gain insight into future interventions to help improve coping and quality of life in people with cancer.

National Institute of Health (NIH)
Academic/Teacher Award (ATA) (K07)
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Subcommittee B - Comprehensiveness (NCI)
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Perkins, Susan N
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Northwestern University at Chicago
Public Health & Prev Medicine
Schools of Medicine
United States
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Zebrack, Brad; Kwak, Minyoung; Salsman, John et al. (2015) The relationship between posttraumatic stress and posttraumatic growth among adolescent and young adult (AYA) cancer patients. Psychooncology 24:162-8
Ravens-Sieberer, Ulrike; Devine, Janine; Bevans, Katherine et al. (2014) Subjective well-being measures for children were developed within the PROMIS project: presentation of first results. J Clin Epidemiol 67:207-18
Salsman, John M; Garcia, Sofia F; Yanez, Betina et al. (2014) Physical, emotional, and social health differences between posttreatment young adults with cancer and matched healthy controls. Cancer 120:2247-54
Peterman, Amy H; Reeve, Charlie L; Winford, Eboni C et al. (2014) Measuring meaning and peace with the FACIT-spiritual well-being scale: distinction without a difference? Psychol Assess 26:127-37
Sanford, Stacy D; Zhao, Fengmin; Salsman, John M et al. (2014) Symptom burden among young adults with breast or colorectal cancer. Cancer 120:2255-63
Salsman, John M; Lai, Jin-Shei; Hendrie, Hugh C et al. (2014) Assessing psychological well-being: self-report instruments for the NIH Toolbox. Qual Life Res 23:205-15
Salsman, John M; Victorson, David; Choi, Seung W et al. (2013) Development and validation of the positive affect and well-being scale for the neurology quality of life (Neuro-QOL) measurement system. Qual Life Res 22:2569-80
Yanez, Betina; Garcia, Sofia F; Victorson, David et al. (2013) Distress among young adult cancer survivors: a cohort study. Support Care Cancer 21:2403-8
Salsman, John M; Butt, Zeeshan; Pilkonis, Paul A et al. (2013) Emotion assessment using the NIH Toolbox. Neurology 80:S76-86
Pilkonis, Paul A; Choi, Seung W; Salsman, John M et al. (2013) Assessment of self-reported negative affect in the NIH Toolbox. Psychiatry Res 206:88-97