This study will evaluate the cost-effectiveness of lung cancer screening in HIV infected (HIV+) persons. Candidate: The primary objective of this application is to support Dr. Keith Sigel's career development into an independent investigator in the field of HIV-associated malignancies. Dr. Sigel's career goal is to improve cancer prevention in HIV+ persons by evaluating the unique harms, benefits and costs associated with cancer screening in this population. His proposed training plan focuses on 3 areas: (1) Cohort Study Design;(2) Decision Analysis;and (3) Cost-effectiveness Analysis. Environment: Mount Sinai is a national leader in research and is one of the top 20 medical schools in NIH funding. It is the largest academic provider of HIV care in New York and has one of the largest lung cancer screening research programs in the world. Research: Cancers are emerging as the leading cause of death in HIV+ persons, and lung cancer accounts for the majority of these deaths. Furthermore, HIV+ persons have more than twice the risk of lung cancer of HIV- persons. Lung cancer screening with low dose computed tomography (LDCT) has demonstrated a considerable mortality benefit among HIV- heavy smokers. An increased risk of lung cancer and a high rate of smoking (>70%) suggests that the HIV+ population is an important high-risk group to target for lung cancer screening. However, frequent prior lung infections in HIV+ persons may cause more false positive screening tests (which may lead to invasive procedures with significant complications). Thus, the harms, benefits and costs associated with lung cancer screening in HIV- persons may be different in HIV+ persons. Therefore, our aims are to: (1) determine the rate of positive screening LDCTs and subsequent clinical evaluations in HIV+ smokers and compare to a similar cohort of previously screened HIV- smokers;(2) estimate harms and benefits of annual LDCT lung cancer screening in HIV+ smokers using a simulation model;and (3) determine the lifetime costs and evaluate the cost-effectiveness of annual LDCT cancer screening vs. usual care in HIV+ smokers. We will conduct a prospective study assessing LDCT screening findings in a cohort of HIV+ smokers, comparing findings to matched HIV- controls from an existing screening study. Using these and other data, we will create a simulation model of lung cancer screening in HIV+ patients. We will then measure costs associated with screening in HIV+ persons to incorporate into our model, providing cost-effectiveness estimates of LDCT screening in HIV+ individuals.

Public Health Relevance

Lung cancer is a major cause of death in the HIV infected population, and lung cancer screening with low dose computed tomography (CT) has been shown to dramatically decrease lung cancer deaths in smokers without HIV infection. High rates of prior lung infections may alter the harms and benefits of lung cancer screening in HIV infected persons. Therefore, in this study we will determine whether lung cancer screening with low dose CT scanning is a safe, efficacious and cost-effective test in persons with HIV infection.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Academic/Teacher Award (ATA) (K07)
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Study Section
Subcommittee B - Comprehensiveness (NCI)
Program Officer
Perkins, Susan N
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Icahn School of Medicine at Mount Sinai
Internal Medicine/Medicine
Schools of Medicine
New York
United States
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Sigel, Keith; Pitts, Robert; Crothers, Kristina (2016) Lung Malignancies in HIV Infection. Semin Respir Crit Care Med 37:267-76
Lin, Jenny J; Ezer, Nicole; Sigel, Keith et al. (2016) The effect of statins on survival in patients with stage IV lung cancer. Lung Cancer 99:137-42
Sigel, Carlie; Cavalcanti, Marcela S; Daniel, Tanisha et al. (2016) Clinicopathologic Features of Colorectal Carcinoma in HIV-Positive Patients. Cancer Epidemiol Biomarkers Prev 25:1098-104
Kale, Minal S; Mhango, Grace; Bonomi, Marcelo et al. (2016) Cost of Intensity-modulated Radiation Therapy for Older Patients with Stage III Lung Cancer. Ann Am Thorac Soc 13:1593-9
Park, Lesley S; Tate, Janet P; Sigel, Keith et al. (2016) Time trends in cancer incidence in persons living with HIV/AIDS in the antiretroviral therapy era: 1997-2012. AIDS 30:1795-806
Woodrell, Christopher; Weiss, Jeffrey; Branch, Andrea et al. (2015) Primary Care-Based Hepatitis C Treatment Outcomes With First-Generation Direct-Acting Agents. J Addict Med 9:405-10
Kale, Minal S; Mhango, Grace; Gomez, Jorge E et al. (2015) Treatment Toxicity in Elderly Patients With Advanced Non-Small Cell Lung Cancer. Am J Clin Oncol :
Sigel, Keith; Veluswamy, Rajwanth; Krauskopf, Katherine et al. (2015) Lung Cancer Prognosis in Elderly Solid Organ Transplant Recipients. Transplantation 99:2181-9
Krauskopf, Katherine; Federman, Alex D; Kale, Minal S et al. (2015) Chronic Obstructive Pulmonary Disease Illness and Medication Beliefs are Associated with Medication Adherence. COPD 12:151-64
Sigel, Carlie S; Edelweiss, Marcia; Tong, Leung Chu et al. (2015) Low interobserver agreement in cytology grading of mucinous pancreatic neoplasms. Cancer Cytopathol 123:40-50

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