Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08AG000684-02
Application #
2001107
Study Section
Special Emphasis Panel (ZAG1-DAG-1 (82))
Project Start
1995-09-14
Project End
2000-08-31
Budget Start
1996-09-13
Budget End
1997-08-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Hujer, Andrea M; Hujer, Kristine M; Helfand, Marion S et al. (2002) Amino acid substitutions at Ambler position Gly238 in the SHV-1 beta-lactamase: exploring sequence requirements for resistance to penicillins and cephalosporins. Antimicrob Agents Chemother 46:3971-7
Hujer, A M; Hujer, K M; Bonomo, R A (2001) Mutagenesis of amino acid residues in the SHV-1 beta-lactamase: the premier role of Gly238Ser in penicillin and cephalosporin resistance. Biochim Biophys Acta 1547:37-50
Bonomo, R A; Knox, J R; Rudin, S D et al. (1997) Construction and characterization of an OHIO-1 beta-lactamase bearing Met69Ile and Gly238Ser mutations. Antimicrob Agents Chemother 41:1940-3
Bonomo, R A; Rudin, S D; Shlaes, D M (1997) OHIO-1 beta-lactamase mutants: Asp179Gly mutation confers resistance to ceftazidime. FEMS Microbiol Lett 152:275-8