Dr. Masoudi will complete his fellowship in cardiology in June 2000, and will join the faculty as an assistant professor of Medicine in the Divisions of Cardiology and Geriatric Medicine at the University of Colorado Health Sciences Center. He has completed the course requirements for the M.S.P.H. degree at the University of Colorado and has been involved with the National Hearth Failure (NHF) Project, a program sponsored by the Health Care Financing Administration to measure and improve the care of Medicare beneficiaries with heart failure. The applicant's long- term goals are to develop a career as an independent investigator in cardiovascular diseases in the older population in an academic setting. His immediate goals are to study patients from the NHF database with heart failure and preserved left ventricular systolic function (LVSF); obtain additional methodological expertise with formal course work; participate in related research in cardiovascular disease in older persons; and participate in clinical cardiology at Denver Health Medical Center. The Environment: Dr. Masoudi's research office will be in Center on Aging Research Section, which houses more than 15 health services researchers dedicated to the study of health care quality and outcomes in the older population. His research mentor is Andrew Kramer, MD, Professor of Geriatric Medicine and Director of the Center on Aging Research Section at the University of Colorado. He will work closely with geriatricians, research methodologists, cardiologists, and his co-sponsors, who are leaders on the NHF Project. The Research: Heart failure with preserved LVSF is reportedly common in the older population. In spite of its high prevalence, relatively little is known about the characteristics of these patients or their health outcomes. The objectives of the proposed research are to describe the population of older Medicare beneficiaries hospitalized across the United States with heart failure and preserved LVSF; identify the determinants of mortality and hospital readmission in this population; and compare risk-adjusted rates of mortality and hospital readmission in this population with those of patients with heart failure and impaired LSVF. To accomplish these aims, we will analyze detailed clinical information from the hospital charts of more than 20,000 patients collected as part of the NHF Project linked to the administrative data sets containing patient-level information. The results of this research will better characterize these patients, will explore the important determinants of patient outcomes, and may provide insights in the development of interventions targeted specifically at this population.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08AG001011-05
Application #
6792742
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Rossi, Winifred K
Project Start
2000-09-15
Project End
2006-08-31
Budget Start
2004-09-01
Budget End
2006-08-31
Support Year
5
Fiscal Year
2004
Total Cost
$120,420
Indirect Cost
Name
University of Colorado Denver
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
Rathore, Saif S; Curtis, Jeptha P; Nallamothu, Brahmajee K et al. (2009) Association of door-to-balloon time and mortality in patients > or =65 years with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. Am J Cardiol 104:1198-203
Vinson, David R; Magid, David J; Brand, David W et al. (2007) Patient sex and quality of ED care for patients with myocardial infarction. Am J Emerg Med 25:996-1003
Shah, Rahman; Wang, Yun; Masoudi, Frederick A et al. (2007) Sex and racial differences in outcomes and guideline-based management of troponin-only-positive acute myocardial infarction in older persons. Am J Geriatr Cardiol 16:97-105
Foody, JoAnne Micale; Rathore, Saif S; Galusha, Deron et al. (2006) Hydroxymethylglutaryl-CoA reductase inhibitors in older persons with acute myocardial infarction: evidence for an age-statin interaction. J Am Geriatr Soc 54:421-30
Rathore, Saif S; Masoudi, Frederick A; Wang, Yongfei et al. (2006) Socioeconomic status, treatment, and outcomes among elderly patients hospitalized with heart failure: findings from the National Heart Failure Project. Am Heart J 152:371-8
Smith, Grace L; Shlipak, Michael G; Havranek, Edward P et al. (2006) Serum urea nitrogen, creatinine, and estimators of renal function: mortality in older patients with cardiovascular disease. Arch Intern Med 166:1134-42
Foody, JoAnne Micale; Shah, Rahman; Galusha, Deron et al. (2006) Statins and mortality among elderly patients hospitalized with heart failure. Circulation 113:1086-92
Morgan, Anne L; Masoudi, Frederick A; Havranek, Edward P et al. (2006) Difficulty taking medications, depression, and health status in heart failure patients. J Card Fail 12:54-60
Ho, P Michael; Rumsfeld, John S; Masoudi, Frederick A et al. (2006) Effect of medication nonadherence on hospitalization and mortality among patients with diabetes mellitus. Arch Intern Med 166:1836-41
Kosiborod, Mikhail; Curtis, Jeptha P; Wang, Yongfei et al. (2005) Anemia and outcomes in patients with heart failure: a study from the National Heart Care Project. Arch Intern Med 165:2237-44

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