Cardiovascular disease is the leading cause of death in the US, and a significant source of racial and socioeconomic disparities in morbidity among aging populations. Chronic inflammation is thought to underlie the pathogenesis of atherosclerosis and the development of cardiovascular disease. There are racial and socioeconomic disparities in biomarkers of cardiovascular inflammation that increase across middle and older age, particularly among women. These disparities are not completely explained by traditional risk factors at the individual level, including behavioral risk factors. Area-level socioeconomic status may influence the incidence of cardiovascular disease by promoting inflammation. The candidate seeks training to investigate the role of metropolitan area and neighborhood level social factors in the pathogenesis of cardiovascular inflammation among aging populations. The proposed research has a novel focus on geographic social determinants of pre-disease risk markers of inflammation. The candidate is trained in Internal Medicine (MD) and Social Epidemiology (SD). The candidate brings experience evaluating social exposures at the individual level among middle-aged and elder adults. Over five years, the candidate will acquire training in (1) physiology and regulation of cardiovascular inflammatory pathways, (2) analytic techniques to integrate geographic data on social factors with biologic data in epidemiologic research, and (3) leadership in interdisciplinary research in diverse and aging populations. This training provides preparation for the candidate's long-term career goal to investigate area-level socioeconomic factors that contribute to pre-disease cardiovascular risk factors in diverse and aging populations. The proposed training program will be mentored by Dr. Lisa Berkman (primary mentor. Social Epidemiologist, social influences on aging, interdisciplinary epidemiology research) and Dr. Paul Ridker (Cardiologist, cardiovascular inflammation in atherosclerosis, cardiac event risk prediction among women). A team of advisors will (1) provide training in geographic analysis, and (2) support working with the two study populations. The proposed research will be conducted in the (1) Women's Health Study (WHS) and the (2) Jackson Heart Study (JHS). Publications stemming from these investigations will enhance scientific understandings of geographic variation in cardiovascular disease risks among middle-aged and elder populations.

Public Health Relevance

Investigators who are trained to investigate connections between social factors and biomarkers of disease risk are needed to guide social and behavioral interventions to reduce the incidence and severity of cardiovascular disease in diverse and aging populations. Connecting geographic level socioeconomic status to biomarkers of inflammation is a new contribution to population-based prevention approaches to CVD risk reduction among elders.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08AG032357-04
Application #
8307837
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Nielsen, Lisbeth
Project Start
2009-09-01
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
4
Fiscal Year
2012
Total Cost
$124,322
Indirect Cost
$9,209
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
Pham, Do Quyen; Ommerborn, Mark J; Hickson, DeMarc A et al. (2014) Neighborhood safety and adipose tissue distribution in African Americans: the Jackson Heart Study. PLoS One 9:e105251
Clark, Cheryl R; Ommerborn, Mark J; Coull, Brent A et al. (2013) State Medicaid eligibility and care delayed because of cost. N Engl J Med 368:1263-5
Clark, Cheryl R; Ommerborn, Mark J; Hickson, DeMarc A et al. (2013) Neighborhood disadvantage, neighborhood safety and cardiometabolic risk factors in African Americans: biosocial associations in the Jackson Heart study. PLoS One 8:e63254
Grooms, Kya N; Ommerborn, Mark J; Pham, Do Quyen et al. (2013) Dietary fiber intake and cardiometabolic risks among US adults, NHANES 1999-2010. Am J Med 126:1059-67.e1-4
Clark, Cheryl R; Ridker, Paul M; Ommerborn, Mark J et al. (2012) Cardiovascular inflammation in healthy women: multilevel associations with state-level prosperity, productivity and income inequality. BMC Public Health 12:211
Clark, Cheryl R; Coull, Brent; Berkman, Lisa F et al. (2011) Geographic variation in cardiovascular inflammation among healthy women in the Women's Health Study. PLoS One 6:e27468