Intensive care medicine represents an area of high intensity, high expenditure treatment with potential for large health benefits and also iatrogenic complications and unnecessary costs. Defining how to care best for an aging population when we have the capability of delivering increasingly complex interventions is a pressing concern. The elderly now represent over half of all intensive care unit (ICU) admissions in the United States, and present unique challenges for care both inside and outside the ICU. Most studies of intensive care medicine examine only those patients who are admitted to the ICU;studies that also include all hospitalized patients as a denominator are rare, yet essential to understanding how intensive care can and should be used. We recently demonstrated that the use of intensive care during terminal hospitalizations decreases with age, and varies substantially depending on the diagnosis or surgical procedure. However, studies of admission practices to ICUs and associated outcomes are confounded by variation in casemix and available resources. We plan to examine the use of intensive care by focusing on elderly patients undergoing specific high-risk surgical procedures - a more homogenous group of patients who are more likely to have a planned ICU admission compared with medical patients. We seek to test the hypotheses that ICU admission practices for elderly patients after high-risk surgical procedures vary significantly by hospital and patient characteristics, and that these variations in practice can be exploited to determine whether there are any measurable health benefits in terms of reduced complications and mortality from more aggressive use of intensive care services. We will test these hypotheses with three aims: (1) identify predictors of ICU admission practices for elderly surgical patients, (2) establish whether ICU admission practices are associated with surgical complication rates and mortality (including both hospital and one-year mortality) and (3) determine the economic consequences of different admission rates to intensive care. We will accomplish these aims through analysis of five years of inpatient Medicare data, as well as an ICU-specific dataset, Project IMPACT, that allows for a more detailed examination of the care patterns of patients prior to ICU admission. This study represents a unique opportunity both to identify ways to optimize peri-operative care, and also to address broader questions related to ICU admission practices and the risks and benefits associated with intensive care. As the availability of intensive care continues to grow, the answers to these questions are of vital importance to improve the delivery of high quality care. This award would allow me to complete the proposed study and also obtain the necessary research skills, experience, and collaborative relationships to develop into a successful and independent clinician-scientist in the area of health services research.

Public Health Relevance

The goal of this proposal is to understand the role of intensive care in providing high quality care for elderly surgical patients. Specifically, we will use Medicare data to identify elderly patients undergoing ten high-risk surgical procedures to determine variation in admission practices to intensive care units and to examine the relationship between admission to intensive care and outcomes, including surgical complications, short-term and long-term mortality. This proposal builds upon previous work identifying low use of intensive care services during terminal hospitalizations in the very elderly, and a continued increased risk of death associated with intensive care in the three years following hospital discharge. Understanding the variation in care patterns and identifying whether intensive care provides benefit in specific elderly populations will allow for the development of targeted improvement initiatives to optimize the delivery of high quality healthcare.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08AG038477-03
Application #
8316185
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Zieman, Susan
Project Start
2010-09-30
Project End
2015-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
3
Fiscal Year
2012
Total Cost
$125,685
Indirect Cost
$9,310
Name
Columbia University (N.Y.)
Department
Anesthesiology
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Hua, May; Halpern, Scott D; Gabler, Nicole B et al. (2016) Effect of ICU strain on timing of limitations in life-sustaining therapy and on death. Intensive Care Med 42:987-94
Moitra, Vivek K; Guerra, Carmen; Linde-Zwirble, Walter T et al. (2016) Relationship Between ICU Length of Stay and Long-Term Mortality for Elderly ICU Survivors. Crit Care Med 44:655-62
Wunsch, Hannah; Gershengorn, Hayley B; Cooke, Colin R et al. (2016) Use of Intensive Care Services for Medicare Beneficiaries Undergoing Major Surgical Procedures. Anesthesiology 124:899-907
Guerra, Carmen; Hua, May; Wunsch, Hannah (2015) Risk of a Diagnosis of Dementia for Elderly Medicare Beneficiaries after Intensive Care. Anesthesiology 123:1105-12
Prin, Meghan; Harrison, David; Rowan, Kathryn et al. (2015) Epidemiology of admissions to 11 stand-alone high-dependency care units in the UK. Intensive Care Med 41:1903-10
Wunsch, Hannah; Harrison, David A; Jones, Andrew et al. (2015) The impact of the organization of high-dependency care on acute hospital mortality and patient flow for critically ill patients. Am J Respir Crit Care Med 191:186-93
Hope, Aluko A; Gong, Michelle N; Guerra, Carmen et al. (2015) Frailty Before Critical Illness and Mortality for Elderly Medicare Beneficiaries. J Am Geriatr Soc 63:1121-8
Hua, May; Gong, Michelle Ng; Brady, Joanne et al. (2015) Early and late unplanned rehospitalizations for survivors of critical illness*. Crit Care Med 43:430-8
Sjoding, Michael W; Prescott, Hallie C; Wunsch, Hannah et al. (2015) Hospitals with the highest intensive care utilization provide lower quality pneumonia care to the elderly. Crit Care Med 43:1178-86
Hua, May S; Li, Guohua; Blinderman, Craig D et al. (2014) Estimates of the need for palliative care consultation across united states intensive care units using a trigger-based model. Am J Respir Crit Care Med 189:428-36

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