Through this K08 application, I request support to facilitate my transition to an independent researcher in statistical genetics as applied to nicotin dependence and comorbid psychiatric disorders. I have a foundation both in statistics and clinical psychiatry, and recent postdoctoral training in psychiatric and addiction genetics. This grant will provide me with the additional training I need in statistical genetics, data collection, grant development, and project management. Using a combination of didactic coursework and supervision with mentors in quantitative genetics (Drs. James Cheverud, and Peter Kraft), addiction genetics (Dr. Laura Bierut), molecular genetics (Dr. Alison Goate), and psychiatric genetics (Dr. Michael Owen), I will develop the expertise needed to become a successful, independent investigator. The research proposed in this application was designed to significantly contribute to the field of addiction genetics, and to complement my career development plan by leveraging the skills of my mentors to help guide me to develop an independent field of study. The three aims are (1) to calculate the proportion of phenotypic variance for nicotine dependence that is explained by the common SNPs in genome-wide association studies (GWAS) to better understand the total amount of information available in the datasets, (2) to examine homogenous subgroups of individuals and compare contrasting subgroups of individuals to find novel loci that are more strongly associated with nicotine dependence, particularly in the context of comorbid psychiatric disorders, and (3) to develop a database to maximize power for discovery of genetic variants that contribute to nicotine dependence. These studies will help me to develop a strong research program that uses my unique combination of quantitative expertise with clinical knowledge to better understand the genetics of smoking and comorbid psychiatric disorders.

Public Health Relevance

Nicotine dependence and smoking continue to be the leading cause of preventable death worldwide. In particular, individuals with other psychiatric disorders including bipolar disorder, schizophrenia, and depression are particularly at risk for the development of dependence and the associated medical risks. The proposed application aims to both solidify our understanding of how genetics contributes to the disorders and investigate whether there are overlapping genetic risk factors for the development of both nicotine dependence and other psychiatric disorders. The results of this study will lead to improved understanding and treatment of these disorders.

Agency
National Institute of Health (NIH)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08DA032680-03
Application #
8655533
Study Section
AIDS Behavioral Research Subcommittee (NIDA)
Program Officer
Kimmel, Heather L
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Washington University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
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Estrada, Elena; Hartz, Sarah M; Tran, Jeffrey et al. (2016) Nicotine dependence and psychosis in Bipolar disorder and Schizoaffective disorder, Bipolar type. Am J Med Genet B Neuropsychiatr Genet 171:521-4
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Hartz, Sarah M; Quan, Tiffany; Ibiebele, Abiye et al. (2016) The significant impact of education, poverty, and race on Internet-based research participant engagement. Genet Med :
Ramnarine, Shelina; Zhang, Juan; Chen, Li-Shiun et al. (2015) When Does Choice of Accuracy Measure Alter Imputation Accuracy Assessments? PLoS One 10:e0137601
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Hartz, Sarah M (2015) My Experience with Direct to Consumer Genetic Testing. Narrat Inq Bioeth 5:208-10
Cavazos-Rehg, P A; Breslau, N; Hatsukami, D et al. (2014) Smoking cessation is associated with lower rates of mood/anxiety and alcohol use disorders. Psychol Med 44:2523-35

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